Results 131 to 140 of about 11,361,094 (291)

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

The impact of sea level rise on developing countries : a comparative analysis [PDF]

Sea level rise (SLR) due to climate change is a serious global threat. The scientific evidence is now overwhelming. Continued growth of greenhouse gas emissions and associated global warming could well promote SLR of 1m-3m in this century, and ...
Dasgupta, Susmita, Jianping Yan, Meisner, Craig, Laplante, Benoit, Wheeler, David   +4 more
core  

A minimal cellulosome‐like system in Cellulosilyticum lentocellum

FEBS Open Bio, EarlyView.
Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan, Amias Alstrom‐Moore, Gary W Black   +2 more
wiley   +1 more source

Global Dataset of Extreme Sea Levels and Coastal Flood Impacts over the 21st Century

Data
A global database of coastal flooding impacts resulting from extreme sea levels is developed for the present day and for the years 2050 and 2100. The database consists of three sub-datasets: the extreme sea levels, the coastal areas flooded by these ...
Ebru Kirezci, Ian Young, Roshanka Ranasinghe, Yiqun Chen, Yibo Zhang, Abbas Rajabifard   +5 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Self‐Regulated Learning Meets AI: Reinterpreting Self‐Regulation, Co‐Regulation, and Socially Shared Regulation in Human–AI Interaction

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Advancing artificial intelligence (AI) has transformed learning and work, yet higher education and professional development programs have not systematically equipped learners for AI‐prevalent environments. This lack of preparation creates uncertainty regarding control, responsibility, trust, and accountability.
Moon‐Heum Cho, Jerusalem Merkebu
wiley   +1 more source

The Role of Calcitonin Gene‐Related Peptide in High‐Altitude Headache: A Prospective Field Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective High‐altitude headache (HAH) is a common neurological condition associated with rapid ascent to high altitude. The pathophysiological mechanisms underlying HAH remain incompletely understood. Calcitonin gene‐related peptide (CGRP), a neuropeptide implicated in migraine pathophysiology, may play a key role in the pathophysiology of ...
Roman Schniepp, Ludwig Karrasch, Helena Breitenstein, Andreas Straube, Katharina Kamm   +4 more
wiley   +1 more source

Worst Case Scenario and Stakeholder Group Decision: A 5-6 Meter Sea Level Rise in the Rhone Delta, France [PDF]

Risk policy and public attitudes appear disconnected from research predicting warmer climate partially due to human activity. To step out of this stalled situation, a worst case scenario of a 5-6m sea level rise (SLR) induced by the collapse of the WAIS ...
Athanasios T. Vafeidis, Marc Poumadere, Claire Mays, Gabriela Pfeifle   +3 more
core  

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Sea Level Rise in Europe: Observations and projections

International audienceSea level rise (SLR) is a major concern for Europe, where 30 million people live in the historical 1-in-100-year event flood coastal plains.
Haigh, Ivan, D, Hermans, Tim, H J, Meier, H, E Markus, Dinu, Irina, Reese, Ronja, van de Wal, Roderik, Simpson, Matthew, J R, Marcos, Marta, Melet, Angélique, Amores, Angel, Lionello, Piero, Slangen, Aimée, B A, Arns, Arne, Meyssignac, Benoit, Palmer, Matthew, D, Chaigneau, Alisée, A   +15 more
core   +1 more source