Results 131 to 140 of about 471,351 (368)

Seasonal to interannual Arctic sea-ice predictability in current GCMs [PDF]

, 2014
We establish the first inter-model comparison of seasonal to interannual predictability of present-day Arctic climate by performing coordinated sets of idealized ensemble predictions with four state-of-the-art global climate models.
Balmaseda, Blanchard-Wrigglesworth, Chevallier, Collins, D. Matei, Day, Donner, E. Hawkins, Goddard, Griffies, Hazeleger, Holland, J. J. Day, Johns, Jungclaus, Kay, Koenigk, Koenigk, M. Collins, Notz, R. Msadek, S. P. E. Keeley, S. Tietsche, Screen, Shaffrey, Sigmond, Smith, Sterl, Tietsche, Tietsche, V. Guemas, W. J. Hurlin, Wang   +32 more
core   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Ecosystem model intercomparison of under-ice and total primary production in the Arctic Ocean [PDF]

, 2016
Previous observational studies have found increasing primary production (PP) in response to declining sea ice cover in the Arctic Ocean. In this study, under-ice PP was assessed based on three coupled ice-ocean-ecosystem models participating in the Forum
Ji, Rubao, Jin, Meibing, Lee, Younjoo J., Pendleton, Daniel, Popova, Ekaterina E., Varpe, Øystein, Yool, Andrew, Zhang, Jinlun   +7 more
core   +2 more sources

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

The interpretation of spikes and trends in concentration of nitrate in polar ice cores, based on evidence from snow and atmospheric measurements [PDF]

, 2008
Nitrate is frequently measured in ice cores, but its interpretation remains immature. Using daily snow surface concentrations of nitrate at Halley (Antarctica) for 2004 - 2005, we show that sharp spikes (> factor 2) in nitrate concentration can occur ...
Bauguitte, S.J.-B., Jones, Anna E., Salmon, Rhian Anya, Wolff, Eric   +3 more
core   +3 more sources

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Towards Sea Ice Remote Sensing with Space Detected GPS Signals: Demonstration of Technical Feasibility and Initial Consistency Check Using Low Resolution Sea Ice Information

Remote Sensing, 2010
This paper presents two space detected Global Positioning System (GPS)signals reflected off sea ice and compares the returned power profiles with independent estimates of ice concentration provided by the Advanced Microwave Scanning Radiometer (AMSR-E ...
Scott Gleason
doaj   +1 more source

Laboratory study on coprecipitation of phosphate with ikaite in sea ice [PDF]

, 2014
Ikaite (CaCO3 6H2O) has recently been discovered in sea ice, providing first direct evidence of CaCO3 precipitation in sea ice. However, the impact of ikaite precipitation on phosphate (PO4) concentration has not been considered so far.
Dieckmann, Gerhard S., Hu, Yu-Bin, Nehrke, Gernot, Wolf-Gladrow, Dieter A.   +3 more
core   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

The Regional Ice Prediction System (RIPS): verification of forecast sea ice concentration

, 2016
In recent years, the demand for improved environmental forecasts in the Arctic has intensified as maritime transport and offshore exploration increase. As a result, Canada has accepted responsibility for the preparation and issuing services for the new ...
J. Lemieux, C. Beaudoin, F. Dupont, F. Roy, Gregory C. Smith, A. Shlyaeva, M. Buehner, A. Caya, Jack Chen, T. Carrieres, L. Pogson, P. DeRepentigny, A. Plante, P. Pestieau, P. Pellerin, H. Ritchie, G. Garric, N. Ferry   +17 more
semanticscholar   +1 more source