Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background and Objectives Ofatumumab, a fully human anti‐CD20 monoclonal antibody, is effective in reducing relapses and disability progression in patients with multiple sclerosis. This study aimed to examine immune profile changes associated with ofatumumab in a prospective cohort of Chinese patients with relapsing–remitting multiple ...
Shu Yang +9 more
wiley +1 more source
Partial Label Learning with Focal Loss for Sea Ice Classification Based on Ice Charts [PDF]
Sea ice, crucial to the Arctic and Earth's climate, requires consistent monitoring and high-resolution mapping. Manual sea ice mapping, however, is time-consuming and subjective, prompting the need for automated deep learning-based classification approaches. However, training these algorithms is challenging because expert-generated ice charts, commonly
arxiv +1 more source
CNS Mitochondria‐Derived Vesicle in Blood: Potential Biomarkers for Brain Mitochondria Dysfunction
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Mitochondrial dysfunction is a hallmark of neurodegenerative diseases like Alzheimer's (AD) and Parkinson's (PD). Our goal was to develop practical, noninvasive methods to assess mitochondrial status through the detection of mitochondria‐derived vesicles (MDVs).
Qi Liu +12 more
wiley +1 more source
SIFM: A Foundation Model for Multi-granularity Arctic Sea Ice Forecasting [PDF]
arXivArctic sea ice performs a vital role in global climate and has paramount impacts on both polar ecosystems and coastal communities. In the last few years, multiple deep learning based pan-Arctic sea ice concentration (SIC) forecasting methods have emerged and showcased superior performance over physics-based dynamical models.
arxiv
Exponentially decaying modes and long-term prediction of sea ice concentration using Koopman mode decomposition. [PDF]
Sci Rep, 2020 Hogg J, Fonoberova M, Mezić I.
europepmc +1 more source
Bayesian Calibration for the Arctic Sea Ice Biomarker IP25 [PDF]
Sea ice plays multiple important roles in regulating the global climate. Rapid sea ice loss in the Arctic has been documented over recent decades, yet our understanding of long‐term sea ice variability and its feedbacks remains limited by a lack of ...
core +1 more source
Intensified Arctic warming under greenhouse warming by vegetation–atmosphere–sea ice interaction [PDF]
Observations and modeling studies indicate that enhanced vegetation activities over high latitudes under an elevated CO2 concentration accelerate surface warming by reducing the surface albedo. In this study, we suggest that vegetation-atmosphere-sea ice
Chen, DL +5 more
core +1 more source
Artificial Receptor in Synthetic Cells Performs Transmembrane Activation of Proteolysis
Advanced Biology, EarlyView.Transmembrane signaling is the hallmark of living cells and is among the highest challenges for the design of synthetic cells. Herein, an artificial receptor based on the chemistry of self‐immolative linkers is used to communicate information across the lipid bilayer, for transmembrane activation of enzymatic activity. Abstract The design of artificial,
Ane Bretschneider Søgaard +7 more
wiley +1 more source
Reduction in seasonal sea ice concentration surrounding southern Baffin Island 1979–2004 [PDF]
, 2006 G. W. K. Moore
openalex +1 more source
Effect of ice algal community on the increase of chlorophyll a concentration during spring in coastal water of the Sea of Okhotsk [PDF]
, 2000 A seasonal study of size fractionated chlorophyll α concentration was conducted weekly in Monbetsu Harbor from October 1996 to November 1997 to investigate the annually persistent occurrence of the spring peak of the chlorophyll α concentration in the ...
Fumio Satoh +5 more
core +1 more source