Results 271 to 280 of about 2,508,802 (334)

Genetic adaptations shaping survival, pregnancy, and life at high altitude and sea level. [PDF]

Philos Trans R Soc Lond B Biol Sci
Gu W, Lawrence ES, Evans AM, Simonson TS.   +3 more
europepmc   +1 more source

Impacts of Along-Strait Winds on Sea Level, Sea Surface Temperature, and Current in the Jeju Strait During Summer 2022 [PDF]

Chang‐Woong Shin, Hong Sik Min, Seok Lee, Kyung‐Hee Oh, Yong Sun Kim, Hyoun‐Woo Kang, Byoungju Choi   +6 more
openalex   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Comparative study on sea-level rise in the Yangtze River Estuary and Red River Estuary in the recent 30 years. [PDF]

Sci Rep
Xue W, Qiao L, Zhang S, Zhong Y, Duan X, Yin P, Liu J.   +6 more
europepmc   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Potential implications of rising sea level on American Horseshoe Crab (Limulus polyphemus) spawning beaches in two Florida counties. [PDF]

PLoS One
Contrada D, Crowley-McIntyre C, Heres B.
europepmc   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Pan-Pacific low-frequency modes of sea level and climate variability. [PDF]

Sci Adv
Little CM, Yeager SG, Fasullo JT, Karnauskas KB, Nerem RS, Etige NS.   +5 more
europepmc   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Reduced Atlantic reef growth past 2 °C warming amplifies sea-level impacts. [PDF]

Nature
Perry CT, de Bakker DM, Webb AE, Comeau S, Harvey BP, Cornwall CE, Alvarez-Filip L, Pérez-Cervantes E, Morris J, Enochs IC, Toth LT, O'Dea A, Dillon EM, Meesters EH, Precht WF.   +14 more
europepmc   +1 more source