Results 61 to 70 of about 66,031 (308)

Year-round records of bulk and size-segregated aerosol composition in central Antarctica (Concordia site) – Part 1: Fractionation of sea-salt particles [PDF]

Atmospheric Chemistry and Physics, 2017
Multiple year-round records of bulk and size-segregated composition of aerosol were obtained at the inland site of Concordia located at Dome C in East Antarctica.
M. Legrand, M. Legrand, S. Preunkert, S. Preunkert, E. Wolff, R. Weller, B. Jourdain, B. Jourdain, D. Wagenbach, D. Wagenbach   +9 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

THE POTENTIALS OF ULTRASONIC ATOMIZER AUGMENTED THE SEA SALT PRODUCTIONS

Logic
Ultrasonic atomizers can potentially augment the production of sea salt through a process known as ultrasonic nebulization. While the traditional method of sea salt production primarily relies on natural evaporation, ultrasonic atomization can accelerate
I Dewa Gede Agus Tri Putra, Putu Wijaya Sunu, Nyoman Sugiartha, I Nyoman Gede Baliarta, I Wayan Temaja   +4 more
doaj   +1 more source

Observationally constrained analysis of sea salt aerosol in the marine atmosphere [PDF]

Atmospheric Chemistry and Physics, 2019
Atmospheric sea salt plays important roles in marine cloud formation and atmospheric chemistry. We performed an integrated analysis of NASA GEOS model simulations run with the GOCART aerosol module, in situ measurements from the PALMS and SAGA ...
H. Bian, H. Bian, K. Froyd, K. Froyd, D. M. Murphy, J. Dibb, A. Darmenov, M. Chin, P. R. Colarco, A. da Silva, T. L. Kucsera, G. Schill, G. Schill, H. Yu, P. Bui, M. Dollner, B. Weinzierl, A. Smirnov   +17 more
doaj   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Modeling sea-salt aerosol in a coupled climate and sectional microphysical model: mass, optical depth and number concentration [PDF]

Atmospheric Chemistry and Physics, 2011
Sea-salt aerosol mass, optical depth, and number concentration over the global oceans have significant implications for aerosol direct and indirect climate effects.
T. Fan, O. B. Toon
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

A sea of salt [PDF]

Canadian Medical Association Journal, 2010
I read with some bemusement the excellent review article “Effective population-wide public health interventions to promote sodium reduction.” [1][1] While the authors are to be commended on their broad overall perspective, a cynical person might suggest that they might temper their enthusiasm ...
openaire   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source