Results 171 to 180 of about 1,684,656 (265)

Lessons from local area special educational needs and disability inspections: A content analysis of Ofsted and Care Quality Commission outcome letters

open access: yesBritish Educational Research Journal, EarlyView.
Abstract The growing concern about demand for, and provision of, support for children and young people with special educational needs and disabilities (SEND) has led the English government to announce a review of the system, which many describe as being in crisis.
Ariadna Albajara Sáenz   +5 more
wiley   +1 more source

Inventory Replenishment and Transshipment for Distributed Autologous Cell Therapy Manufacturing Networks

open access: yesBiotechnology and Bioengineering, EarlyView.
ABSTRACT Autologous cell therapy (AuCT) manufacturing networks must balance two competing objectives: reducing cost and improving patient access to time‐sensitive therapy. This study compares three AuCT manufacturing network designs: a centralized network with a single manufacturing facility, a coordinated point‐of‐care (POC) network in which POCs can ...
Zhaowei Li   +3 more
wiley   +1 more source

Mechanistic Analysis of Drug Linker Clearance During Ultrafiltration/Diafiltration of an Antibody–Drug Conjugate

open access: yesBiotechnology and Bioengineering, EarlyView.
ABSTRACT Ultrafiltration/diafiltration (UF/DF) is a key unit operation in the manufacture of antibody‐drug conjugates (ADCs), commonly utilized for post‐conjugation purification to remove residual Drug Linker (DL) compounds and affect buffer exchange.
Vasudev Tangry   +5 more
wiley   +1 more source

Unmasking Glycoforms: Lectin‐Based Profiling and Functional Implications of Targeted Glycosylation Knockouts in Chinese Hamster Ovary Cells

open access: yesBiotechnology and Bioengineering, EarlyView.
ABSTRACT Monoclonal antibody (mAb) glycosylation is a critical quality attribute that is difficult to rationally engineer and rapidly assess during cell line development. Here, we investigate whether cell‐surface glycosylation can serve as a surrogate readout of mAb product glycosylation following targeted glycogene engineering in CHO cells.
Cristina Abascal Ruiz   +6 more
wiley   +1 more source

Scale‐Down Platforms for Process‐Oriented Enzyme Screening Using Microfluidics

open access: yesBiotechnology and Bioengineering, EarlyView.
ABSTRACT Enzyme screening platforms are typically evaluated based on their throughput and analytical performance rather than their ability to mimic the conditions encountered at large scale. In bioreactors, enzymes experience gradients in substrate concentration, oxygen availability, pH, temperature, and interfacial exposure, caused by imperfect mixing
Maria I. Rodriguez‐Torres   +5 more
wiley   +1 more source

Tackling cancer stemness with nanotechnology in the era of precision medicine

open access: yesBMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo   +9 more
wiley   +1 more source

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