Results 211 to 220 of about 15,037 (310)

DNA methylation landscape of Nautilus Pompilius. [PDF]

open access: yesBMC Genomics
Wu Y   +7 more
europepmc   +1 more source

Depletion of the RNA‐Editing Enzyme ADAR1 Invigorates the Antitumor Immunity of NK Cells

open access: yesAdvanced Science, EarlyView.
ADAR1 is upregulated in NK cells from melanoma patients, impairing their function. Its loss enhances NK cell tumor infiltration and cytotoxicity in vitro and in vivo. Mechanistically, ADAR1 deficiency destabilizes CD38 mRNA to reduce its expression, thereby increasing NK cell mobility and killing, which nominates it as a therapeutic target for NK cell ...
Shuhan Chen   +11 more
wiley   +1 more source

Conservation of cis-Regulatory Syntax Underlying Deuterostome Gastrulation. [PDF]

open access: yesCells
Buono L   +8 more
europepmc   +1 more source

Therapeutic effect and titers of the specific IgE and IgG antibodies in patients with sea squirt Allergy (Hoya asthma) under a long-term hyposensitization with three sea squirt antigens

open access: bronze, 1989
Toshihiko Jyo   +9 more
openalex   +1 more source

Non‐Targeting shRNA‐Encoded Plasmid DNA Enhances Protective Immunity Through RIDD‐RIG‐I Signaling Pathway in the Zika Virus Animal Model

open access: yesAdvanced Science, EarlyView.
We present a novel DNA vaccine platform featuring intrinsic, non‐targeting dsRNA that significantly enhances immune responses by activating the regulated IRE1‐dependent decay‐RIG‐I signaling pathway. This research elucidates a previously uncharacterized mechanism for dsRNA‐mediated innate immune activation.
Min‐Syuan Huang   +10 more
wiley   +1 more source

Transforming Grain‐Boundary Brittle Precipitates to Ductility Pathways in Complex Concentrated Alloy

open access: yesAdvanced Science, EarlyView.
By engineering graded BCC/L12 interfaces, brittle precipitates in a complex concentrated alloy enable sequential deformation, realizing gigapascal strength with >20% elongation to solve the strength‐ductility trade‐off. ABSTRACT Conventional wisdom holds that hard grain‐boundary (GB) precipitates embrittle structural alloys by acting as crack ...
Zhixin Li   +14 more
wiley   +1 more source

New Compounds From the Deep-sea Sponge Mycale lingua. [PDF]

open access: yesChem Biodivers
Clark HP   +8 more
europepmc   +1 more source

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