Results 141 to 150 of about 21,598 (256)

Draft genome sequence of <i>Vibrio pectenicida</i> strain FHCF-3, a causative agent of sea star wasting disease in the sunflower sea star (<i>Pycnopodia helianthoides</i>), reveals the genetic potential to produce aerolysin-like toxins. [PDF]

Microbiol Resour Announc
Zhong KX, Chan AM, Prentice MB, Gouin Y, Harvell D, Gehman A-LM, Suttle CA.   +6 more
europepmc   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Manganese Uptake and Lethality in the Sea Star Asterias rubens: Effect of Hypoxia. [PDF]

Bull Environ Contam Toxicol
Bjerregaard P, Hansen SN.
europepmc   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Analytical and machine learning approaches identify a sea star steroid with promising activity for COVID-19 therapeutic development. [PDF]

Sci Rep
Abd El Hafez MSM, Maiyza AI, Hassan HA, Osama S, Seadawy MG, El Demellawy MA, Ghareeb DA.   +6 more
europepmc   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Sunflower sea star chemical cues locally reduce kelp consumption by eliciting a flee response in red sea urchins. [PDF]

Proc Biol Sci
Mancuso RT, Gravem SA, Campbell RS, Hunter N, Raimondi P, Galloway AWE, Kroeker KJ.   +6 more
europepmc   +1 more source

Role of Sea Star Platelets, of Sea Star Lymphocytes in Invertebrates

Acta Scientific Pharmaceutical Sciences, 2019
openaire   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

New Polyhydroxysteroid Glycosides with Antioxidant Activity from the Far Eastern Sea Star Ceramaster patagonicus. [PDF]

Mar Drugs
Malyarenko TV, Zakharenko VM, Kicha AA, Ponomarenko AI, Manzhulo IV, Kalinovsky AI, Popov RS, Dmitrenok PS, Ivanchina NV.   +8 more
europepmc   +1 more source