Results 181 to 190 of about 7,079,056 (224)

Complex traces: Examining morbidity and mortality among 19th Century migrants to South Australia using a Complex Adaptive Systems framework. [PDF]

PLoS One
Gurr A, Brook O'Donnell M, Brook AH.
europepmc   +1 more source

Molecular Glue Degraders Enhance CAPRIN1‐Dependent Lysosomal Degradation of APP and Reduce Amyloid β in Alzheimer's Disease

Advanced Science, EarlyView.
A new class of lysosome‐directed molecular glue degraders selectively enhance CAPRIN1–APP interactions, driving APP degradation and reducing amyloid‐β production in human neurons and Alzheimer's disease mouse models. This CAPRIN1‐dependent targeted protein degradation strategy reveals a previously unrecognized therapeutic approach for disrupting the ...
Sunghan Jung, Xu Wang, Bin Liu, Raktim Roy, Nancy Jaiswal, Ratan K. Rai, Yuichiro Takagi, Cen Gao, Lifan Zeng, Ho‐Yin Lo, Reagan K. Wohlford, Ryan K. Higgins, Bruce T. Lamb, Anantha Shekhar, Anita C. Bellail, Chunhai Hao   +15 more
wiley   +1 more source

Consequences of kelp forest ecosystem shifts and predictors of persistence through multiple stressors. [PDF]

Proc Biol Sci
Smith JG, Malone D, Carr MH.
europepmc   +1 more source

TH/TRs–COL11A2 Axis Mediates Loss of a Differentiated Astrocyte State in Hypogyrified Brains

Advanced Science, EarlyView.
Using a gyrencephalic congenital hypothyroidism pig model, this study reveals cerebral atrophy and cortical hypogyrification. Single‐cell sequencing identifies astrocytes as major TH‐responsive cells, with the COL11A2‐enriched Astro‐2 state nearly absent.
Ying Zhang, Xiao Wang, Hongyan Ma, Pengcheng Lyu, Shuangjie Tian, Ruojun Zong, Jiani Chen, Gang Ren, Yongjiang Yang, Zichen Yang, Guosong Qin, Naishi Li, Yanfang Wang, Jianwei Jiao, Jianguo Zhao   +14 more
wiley   +1 more source

Antarctic seep emergence and discovery in the shallow coastal environment. [PDF]

Nat Commun
Seabrook S, Law CS, Thurber AR, Ladroit Y, Cummings V, Tait L, Maurice A, Hawes I.   +7 more
europepmc   +1 more source

Layer‐Specific Dermal and Subcutaneous Delivery via Modular LNP–Hydrogel‐Integrated Threaded Microneedles

Advanced Science, EarlyView.
Guided by spatial transcriptomics and clinical validation, a threaded microneedle platform enables precise layer‐specific delivery across the dermis and subcutaneous tissue. By addressing distinct pathogenic remodeling in different skin layers, this strategy coordinates compartment‐specific intervention, restores tissue architecture, and offers a ...
Fangzhou Xie, Yixiang Zhang, Shifeng Ling, Yuxuan Huang, Yingying Wei, Rao Fu, Jiahao He, Baikun Liu, Lucia Zhou, Kaifeng Huo, Yida Wang, Qingfeng Li, Yawei Du, Wenguo Cui, Yun Xie   +14 more
wiley   +1 more source

Cave adaptation favors aging resilience in the Mexican tetra. [PDF]

NPJ Metab Health Dis
Cobham AE, Kenzior A, Morales-Sosa P, Javier JE, Swanson S, Wood C, Rohner N.   +6 more
europepmc   +1 more source

Probing the Energy Landscape of α‐Synuclein Amyloid Fibril Formation by Systematic K‐to‐Q Mutagenesis

Advanced Science, EarlyView.
We use lysine‐to‐glutamine mutations to study the effect of electrostatics on the kinetics and thermodynamics of alpha‐synuclein amyloid fibril formation. We find that mutational effects map on their structural context within fibrils and identify residues that modulate the energy landscape of alpha‐synuclein self‐assembly. Our work outlines a scalable,
Antonin Kunka, Azad Farzadfard, Jacob Aunstrup Larsen, Rasmus Krogh Norrild, Federica Saraceno, Celia Fricke, Hossein Mohammad‐Beigi, Ahmed Sadek, Jonas Folke, Susana Aznar, Alexander K. Buell   +10 more
wiley   +1 more source

Community-led management maintains higher predator biomass supporting kelp forests persistence in Baja California. [PDF]

Sci Rep
Bauer J, Beas-Luna R, Malpica-Cruz L, Abadía-Cardoso A, Filz P, Bonilla JC, Lorda J.   +6 more
europepmc   +1 more source

Multiple resiliency metrics reveal complementary drivers of ecosystem persistence: An application to kelp forest systems. [PDF]

Ecology
Arroyo-Esquivel J, Adams R, Gravem S, Whippo R, Randell Z, Hodin J, Galloway AWE, Gaylord B, Baskett ML.   +8 more
europepmc   +1 more source