Results 71 to 80 of about 7,079,056 (224)

Bi‐ and Mono‐Allelic RFC1 Expansion in a North American Cohort With Idiopathic Axonal Neuropathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective RFC1 biallelic repeat expansion is increasingly recognized as a cause of chronic idiopathic axonal polyneuropathy (CIAP), but it remains challenging to know who to test. This study aims to determine the prevalence of biallelic and monoallelic RFC1 expansions and their corresponding neuropathy phenotypes in CIAP patients and identify ...
Amro M. Stino, Lavanya Muthukumar, Evan L. Reynolds, Peter Todd, Sinem Ovunc, Sheng Chih Jin, Zitian Tang, Simone Thomas, PNRR Study Group, Ahmet Höke, Brian C. Callaghan, Sarah Berth, Vinay Chaudhry, David Cornblath, Leana Doherty, Lindsey Hayes, Hristelina Ilieva, Thomas Lloyd, Mohammad Khoshnoodi, Brett McCray, Brett Morrison, Bipasha Mukherjee‐Clavin, Lyle Ostrow, Michael Polydefkis, Ricardo Roda, Charlotte Sumner   +25 more
wiley   +1 more source

Ecological causes and consequences of Sea Star Wasting Syndrome on the Pacific coast [PDF]

, 2018
Disease outbreaks are becoming more frequent as anthropogenic changes to ecosystem function stress species and create conditions favorable for pathogen infection.
Moritsch, Monica
core   +1 more source

Metapopulation‐scale resilience to disease‐induced mass mortality in a keystone predator: From stasis to instability

Ecosphere
Mass mortality from disease epidemics challenges the resistance and resilience of populations and communities. Assessing the impacts and consequences of such events is crucially dependent on long‐term datasets.
Sarah A. Gravem, Bruce A. Menge
doaj   +1 more source

Digital Cognitive Testing in Mitochondrial Disease: Validity and Challenges for Clinical Trial Use

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Primary mitochondrial disease is a group of genetic disorders caused by pathogenic variants in nuclear or mitochondrial DNA, often resulting in progressive neurodegeneration and cognitive decline. Current management is primarily supportive, though recent research offers hope for disease‐modifying treatments in the future.
Oksana Pogoryelova, Jan Smeitink, Herma Renkema, Rosabeth White, Frankie Barton, Rachel Lyon, Jane Newman, Aye Moe, Yi Shiau Ng, Grainne Siobhan Gorman   +9 more
wiley   +1 more source

Precursors of Sea Star Wasting: Immune and Microbial Disruption During Initial Disease Outbreak in Southeast Alaska

Proceedings of the Royal Society B: Biological Sciences
Abstract Sea Star Wasting Disease (SSW) has devastated sea star populations along the North American Pacific coast since 2013, yet the mechanisms of disease progression, particularly in natural environments, remain unclear.
Andrew R. McCracken, Aly Rodger, Chanchal Saratkar, Sage Mariani Sularz, Sophia Brusch, Joaquin C. B. Nunez, Melissa H. Pespeni   +6 more
openaire   +2 more sources

Diabetes‐Associated Cognitive Impairment: Pathophysiology and Emerging Therapies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Diabetes‐associated cognitive impairment (DACI) is a common yet underrecognized condition, manifesting along a spectrum from mild cognitive impairment to dementia. DACI encompasses patients who develop vascular dementia (VaD) or Alzheimer's disease (AD) with diabetes as a risk factor; however, in certain patients, particularly those lacking ...
Osman Corbali, Priyanka Menon, Halil I. Corbali, Ram Jagannathan, Allan I. Levey   +4 more
wiley   +1 more source

Effects of diet, temperature, salinity and season on wasting disease in ecologically important predatory sea stars

, 2014
This study investigates sea star wasting disease seen in ecologically important predatory sea stars on intertidal coasts of San Juan Island, Lopez Island and Orcas Island (Washington, United States).
Ni, Zhongran, Eisenlord, Morgan, Dethier, Megan   +2 more
core  

Posterior Disconnection Syndrome in Early‐Stage Adult‐Onset Cerebral Adrenoleukodystrophy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Adult‐onset cerebral adrenoleukodystrophy is potentially treatable but often difficult to recognize before advanced cerebral involvement. Herein, we describe three men with early‐stage disease who initially presented with subtle visual complaints rather than subcortical dementia. Targeted neuropsychological testing revealed higher‐order visual
Kazuto Katsuse, Takashi Matsukawa, Yumiko Nakamura, Kazuo Kakinuma, Shoko Ota, Ryo Hara, Saki Nakashima, Kaoru Ito, Yutaro Nakamori, Toshiyuki Kakumoto, Masashi Hamada, Shigenori Kanno, Kyoko Suzuki, Tatsushi Toda   +13 more
wiley   +1 more source

Sea star microbiome and potential role in sea star wasting disease

, 2018
During the summer of 2013, Pisaster ochraceus experienced a mass die-off event due to a poorly understood syndrome called sea star wasting disease (SSWD). Symptoms prior to death included lesions, limb detachment, and tissue degradation. Since then, SSWD
Riley, Serena, McHugh, Cassandra
core  

Vibrio pectenicida strain FHCF-3 is a causative agent of sea star wasting disease

More than ten years following the onset of the sea star wasting disease (SSWD) epidemic, affecting over 20 asteroid species from Mexico to Alaska, the causative agent has been elusive.
Zhong, Kevin, Davis, Katherine, Prentice, Melanie, Finke, Jan, Prentice, Carolyn, McCracken, Andrew, Carvalho, Rute, Kellogg, Colleen, Hershberger, Paul, Hodin, Jason, Crandall, Grace, Harvell, C., Suttle, Curtis, Chan, Amy, Gehman, Alyssa-Lois   +14 more
core   +1 more source