Distinct Lipid Compositions in Seawater and the Sea Surface Microlayer Measured with Liquid Chromatography and High-Resolution Mass Spectrometry. [PDF]
Birt AE +4 more
europepmc +1 more source
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
In situ deep-sea surface-enhanced Raman scattering sensor reveals cyanide as a key factor in cold seep nitrogen cycling. [PDF]
Wang S +12 more
europepmc +1 more source
Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara +10 more
wiley +1 more source
Recalculating the Surface Ocean CO<sub>2</sub> Atlas (SOCAT) to a sea surface temperature climate data record. [PDF]
Ford DJ +12 more
europepmc +1 more source
Remote Sea Surface Temperature Variations during ENSO: Evidence for a Tropical Atmospheric Bridge
S. Klein, B. Soden, N. Lau
semanticscholar +1 more source
USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna +8 more
wiley +1 more source
First spaceborne observation of sea surface height using GPS‐Reflectometry
M. Clarizia +3 more
semanticscholar +1 more source
Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau +9 more
wiley +1 more source
Sea surface suspended concentrations prediction based on pre-trained transformer. [PDF]
Su T, Wang L, Song Y, Bai Z.
europepmc +1 more source

