Results 151 to 160 of about 9,437,769 (262)

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Alkenone indices, sea surface temperature estimates of sediment core GeoB3388-1

, 2012
Alkenone indices, sea surface temperature estimates of sediment core GeoB3388-
Mollenhauer, Gesine, Rainer Gersonde (6961220), Samuel Nunez-Ricardo (6977819), Antoni Rosell-Melé (6967460), Martínez-García, Alfredo, Gesine Mollenhauer (6965003), Dierk Hebbeln (6886385), Gersonde, Rainer, Tiedemann, Ralf, Nunez-Ricardo, Samuel, Mahyar Mohtadi (6886382), Hebbeln, Dierk, Ho, Sze Ling, Frank Lamy (6958274), Mohtadi, Mahyar, Alfredo Martínez‐García (7193519), Rosell-Melé, Antoni, Sze Ling Ho (6977813), Ralf Tiedemann (6886628), Lamy, Frank   +19 more
core   +1 more source

Solar signals in sea level pressure and sea surface temperature

, 2010
We investigate solar cycle signals in 150 years of Sea Level Pressure (SLP) and Sea Surface Temperature (SST) data, using multiple regression analysis. We detect a solar signal in both SLP and SST in the North Pacific during DJF, similar to that found by Van Loon et al. (2007) but of smaller magnitude. We do not, however, identify the signal they found
openaire   +3 more sources

Historical and future maximum sea surface temperatures

Science Advances
Marine heat waves affect ocean ecosystems and are expected to become more frequent and intense. Earth system models’ ability to reproduce extreme ocean temperature statistics has not been tested quantitatively, making the reliability of their future projections of marine heat waves uncertain.
Cael, B. B., Burger, Friedrich A., Henson, Stephanie A., Britten, Gregory L., Frölicher, Thomas L.   +4 more
openaire   +3 more sources

ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function

FEBS Open Bio, EarlyView.
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley, Luke W. Molesworth, Nethma H. Waduge, Fahimeh Eskandari, Peter R. Boag, Gregory M. Davis   +5 more
wiley   +1 more source

Statistical Modes and Physical Drivers of Multidecadal Sea Surface Temperature Variability in the Northwest Atlantic

, 2022
Variations in ocean temperature and the presence of large multidecadal sea surface temperature (SST) oscillation can have a severe impact on Northwest Atlantic ecosystems and fisheries. Differences between historical SST datasets in the regions have also
Coyne, Jonathan
core  

Response of sea surface temperature to atmospheric rivers

Nature Communications
Atmospheric rivers (ARs), responsible for extreme weather conditions, are mid-latitude systems that can cause significant damage to coastal areas. While forecasting ARs beyond two weeks remains a challenge, past research suggests potential benefits may come from properly accounting for the changes in sea surface temperature (SST) through air&#8211 ...
Tien-Yiao Hsu, Matthew R. Mazloff, Sarah T. Gille, Mara A. Freilich, Rui Sun, Bruce D. Cornuelle   +5 more
openaire   +4 more sources

KDAC6 alters cell morphology and motility through positive and negative modulation of F‐actin distribution

FEBS Open Bio, EarlyView.
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph, Andrea B. Pham, Kiara E. Bornes, Razan H. Hammad, Chelsea A. Rousseve‐Ross, Thomas M. Huckaba, Terry J. Watt, Tasha B. Toro   +7 more
wiley   +1 more source

Future increases in Eurasian mid-latitude winter temperature variability shaped by a weakened Atlantic Meridional Overturning Circulation

Communications Earth & Environment
Climate models project reduced temperature variability in Northern high latitudes due to global warming, but impacts on mid-latitude variability remain uncertain. Here, using multi-model simulations from the Coupled Model Intercomparison Project, we find
Sangwoo Lee, Hyo-Seok Park, Maeng-Ki Kim, Seung-Ki Min, Hyokyeong Hwang   +4 more
doaj   +1 more source

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source