Results 201 to 210 of about 18,937 (288)

FHIR-Former: enhancing clinical predictions through Fast Healthcare Interoperability Resources and large language models. [PDF]

J Am Med Inform Assoc
Engelke M, Baldini G, Kleesiek J, Nensa F, Dada A.   +4 more
europepmc   +1 more source

Full‐Body AI Agent: A Perspective on Multi‐Scale Collaborative AI for Systemic Biology and Precision Medicine

Advanced Science, EarlyView.
We propose the Full‐Body AI Agent, a multi‐scale collaborative framework with 7 biological‐layer agents. It unifies multi‐omics/clinical data via standardized protocols, enabling phenotype‐guided closed‐loop reasoning, quantitative evaluation, and LLM safeguards, with promising applications in tumor metastasis modeling and precision drug development ...
Aoqi Wang, Jiajia Liu, Jianguo Wen, Yangyang Luo, Zhiwei Fan, Liren Yang, Xi Hu, Ruihan Luo, Yankai Yu, Sophia Li, Weiling Zhao, Xiaobo Zhou   +11 more
wiley   +1 more source

Innovation in geriatrics: what this series means for care. [PDF]

Innov Aging
Chellappa R.
europepmc   +1 more source

Cis‐ and Trans‐Regulatory Factors Independently Shape Phenotypic Heterogeneity of Retinitis Pigmentosa

Advanced Science, EarlyView.
A zebrafish model carrying an identical human RHO S334X allele reveals two independent genetic layers shaping retinitis pigmentosa (RP) severity: a protective 3‐bp cis‐regulatory insertion that attenuates transgene expression, and a dominant trans‐acting modifier that restores a severe phenotype.
Cong Cui, Kotone Nakagawa, Takumi Tateno, Ayaka Dan, Dexin Meng, Yoshihiro Omori, Soma Tomihara, Suzuri Okamoto, Shigeru Sato, Motokazu Tsujikawa   +9 more
wiley   +1 more source

Network toxicology & molecular docking: endocrine-disrupting chemicals induce prostate cancer - a system study. [PDF]

Int J Clin Exp Pathol
Zhou Y, Zhou GM, Zhang YJ, Deng CH, Li ZS, Hu XD.   +5 more
europepmc   +1 more source

Recent Advances in Laser‐Induced Graphene‐Based Gas Sensors: From Sensing Mechanisms to Biomedical Applications

Advanced Science, EarlyView.
Laser‐induced graphene (LIG) provides a scalable, laser‐direct‐written route to porous graphene architecture with tunable chemistry and defect density. Through heterojunction engineering, catalytic functionalization, and intrinsic self‐heating, LIG achieves highly sensitive and selective detection of NOX, NH3, H2, and humidity, supporting next ...
Md Abu Sayeed Biswas, Ankan Dutta, Shuvendu Das, Abu Musa Abdullah, Wanqing Zhang, Fatema Tuz Zohra, Huanyu Cheng   +6 more
wiley   +1 more source

iS2C2: a cointelligent platform for mechanistic discovery of disease cellular crosstalk. [PDF]

Signal Transduct Target Ther
Sheng J, Ahn JY, Yang L, Wan Z, Qi S, Yu X, Xu Z, Cao Y, Vasquez M, Irfan A, Zhu Y, Zhao H, Yin Z, Zhu Y, Ding Y, Faridar A, Wang L, Liu F, Wang H, Ji Z, Mao D, Chan M, Kermany D, Dong W, Kim DY, Zhang XH, Wong STC.   +26 more
europepmc   +1 more source

β‐Elemene Rescues Radiation‐Induced Enteritis by Orchestrating a Host‐Microbiome Circuit That Fuels Epigenetic DNA Repair

Advanced Science, EarlyView.
This study elucidates that β‐elemene promotes cellular uptake of L. gasseri‐derived lactate by enhancing the membrane translocation of MCT1 in a CD147‐dependent manner. Intracellular lactate, through the lactylation of RBBP4 at the K26 site, recruits EP300 to the promoter regions of downstream genes (POLD1/POLD3), catalyzing H3K27ac modification.
Jiancheng He, Jiapeng Bao, Shukang Deng, Weijie Zang, Haoming Yan, Zihao Zhao, Guangze Zhang, Ruiqing Liu, Junjie Chen, Yilin Hu, Wanjiang Xue   +10 more
wiley   +1 more source

Artificial intelligence-based prediction of esophageal adenocarcinoma risk in Barrett's esophagus patients: a literature review. [PDF]

Transl Gastroenterol Hepatol
Ahuja P, Gangwani MK, Ahuja N, Kamal F, Shah Y, Ali H, Aziz M, Ali MA, Inamdar S.   +8 more
europepmc   +1 more source