Results 131 to 140 of about 53,745 (331)
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Railway station development in post-industrial Rotterdam - path dependency and shifting priorities [PDF]
The combined effects of industrial decline and the development of a service economy currently bring about a change in urban economies. Accessibility, proximity and an attractive urban climate are considered important factors of urban competitiveness ...
Jan Jacob Trip
core
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
How to Auction an Essential Facility When Underhand Integration Is Possible [PDF]
Regulating seaports is difficult in general, even more so for the weak regulatory institutions common in developing countries. For this reason some countries have awarded these facilities via Demsetz auctions, to the port operator that bids the lowest ...
Alexander Galetovic +2 more
core
Adjustment of fifth grade social studies material on Mexico for children reading below grade level [PDF]
, 1961 Thesis (Ed.M.)--Boston ...
Wernick, Gertrude M., Young, Eleanor R.
core +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Beyond geographic path dependencies: towards a post-structuralist approach of the port-city interface [PDF]
, 2015 Technological breakthroughs in the maritime transport industry gave rise to multimodality and global supply chains (Olivier & Slack, 2006). The high competitive character of this maritime transport industry induced transnational corporations (TNCs) to ...
Van den Berghe, Karel
core
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
DEEPWATHER CONTAINER TERMINAL DCT. GENESIS AND REALIZATION OF INVESTMENTS
Contemporary Economy, 2016 Seaports play a very important role in the development of cities, regions and affect the welfare of the residents. They provide jobs, and drive the economy.
Magdalena Adamowicz
doaj