Results 41 to 50 of about 47,972 (355)

Two Faces of NOTCH1 in Childhood Lymphoblastic T‐Cell Neoplasia: Prognostic Divergence of Mutational and Structural Aberrations

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT In pediatric patients, T‐cell lymphoblastic lymphoma (T‐LBL) survival exceeds 80%. Relapse remains associated with limited curative options. Frontline treatment is largely extrapolated from T‐cell acute lymphoblastic leukemia (T‐ALL) treatment, reflecting the ongoing debate, whether both entities represent distinct diseases or variants within ...
Marie C. Heider   +4 more
wiley   +1 more source

Clinical and Biological Features of Response in Resistant Neuroblastoma to 131I‐Metaiodobenzylguanidine Radiotherapy in the Anti‐GD2 Immunotherapy Era

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background 131I‐metaiodobenzylguanidine (131I‐MIBG) radiotherapy is a key treatment for relapsed and refractory (R/R) neuroblastoma (NB). Patients with R/R disease treated in the modern era are increasingly exposed to anti‐GD2 immunotherapy, which exerts selective pressure and may modify both tumor cell state and microenvironment.
Benjamin J. Lerman   +7 more
wiley   +1 more source

Threat Utility of the Seaport Risk Factors: Use of Rough Set-Based Genetic Algorithm

open access: yesJournal of Marine Science and Engineering, 2022
The threat due to risk factors disrupts supply chain continuity. To ensure supply chain continuity, it is important to understand the interdependency between seaport risk factors and the threat of supply chain disruption, from an economic and risk ...
Muhammad Reza Do Bagus, Shinya Hanaoka
doaj   +1 more source

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Maritime Risk in Seaport Operation: A Cross-Country Empirical Analysis with Theoretical Foundations

open access: yesAsian Journal of Shipping and Logistics, 2018
The maritime industry has witnessed several accidents worldwide. These disasters have raised the awareness of both researchers and policy makers about the importance of risk assessment and safety in marine transportation and seaport operation. This study
Hyuk Soo Cho   +2 more
doaj   +1 more source

Towards Smart Port Infrastructures: Enhancing Port Activities Using Information and Communications Technology

open access: yesIEEE Access, 2020
In this digital age, ports face stiff competition in global supply chain. Smart ports, as high performing ports, utilize information and communications technology (ICT) to provide a wide range of smart applications, resulting in vastly improved vessels ...
Kok-Lim Alvin Yau   +4 more
doaj   +1 more source

Implementation Problems of the Rules About the Prevention of Marine Environment Pollution by Sewage and Harmful Substances [PDF]

open access: yesLex Portus, 2018
The article deals with the peculiarities of the implementation process of the conventional rules about the prevention of marine environment pollution by sewage from ships and transported harmful substances in the national legislation of Ukraine.
Oleksandr Balobanov, Stefaniia Shmygina
doaj   +1 more source

Ancient harbour infrastructure in the Levant: tracking the birth and rise of new forms of anthropogenic pressure

open access: yes, 2014
Beirut, Sidon and Tyre were major centres of maritime trade from the Bronze Age onwards. This economic prosperity generated increased pressures on the local environment, through urbanization and harbour development.
Carayon, N.   +3 more
core   +4 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

Risk measures of load loss during service of refrigerated containers in seaports [PDF]

open access: yesArchives of Transport, 2015
The presented paper is concerned with the problems of assessing the risk level for service chain of refrigerated containers in seaports. This issue has been examined with regard to the losses related to the loss of cargo’s qualitative values.
Ludmiła Filina-Dawidowicz   +2 more
doaj   +1 more source

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