Results 71 to 80 of about 53,745 (331)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Adaptive performance optimization for large-scale traffic control systems [PDF]

, 2011
In this paper, we study the problem of optimizing (fine-tuning) the design parameters of large-scale traffic control systems that are composed of distinct and mutually interacting modules.
Aboudolas, K(), Kosmatopoulos Ilias(http://users.isc.tuc.gr/~ikosmatopoulos), Kouvelas Anastasios(http://users.isc.tuc.gr/~akouvelas), Papageorgiou Markos(http://users.isc.tuc.gr/~mpapageorgiou), Κοσματοπουλος Ηλιας(http://users.isc.tuc.gr/~ikosmatopoulos), Κουβελας Αναστασιος(http://users.isc.tuc.gr/~akouvelas), Παπαγεωργιου Μαρκος(http://users.isc.tuc.gr/~mpapageorgiou)   +6 more
core   +2 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Technological trajectories and scenarios in seaport digitalization

, 2021
Digitalization has become a widely used term both in professional language and in scientific literature. It may be seen as a manifestation of technological progression which has been traditionally given a strong emphasis in theories of economic growth ...
T. Inkinen, Reima Helminen, Janne Saarikoski   +2 more
semanticscholar   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Analysis of the seaport value chain as a method for assessing its strategic potential

SHS Web of Conferences, 2018
The aim of the paper is to describe the analysis of the seaport value chain as a method for assessing its strategic potential. This potential is understood as the port's ability to develop and improve its competitive position in sectors that are defined ...
Montwiłł Andrzej
doaj   +1 more source

Drivers of Land Use Conflicts in Infrastructural Mega Projects in Coastal Areas: A Case Study of Patimban Seaport, Indonesia

, 2021
Coastal areas are particularly sensitive because they are complex, and related land use conflicts are more intense than those in noncoastal areas. In addition to representing a unique encounter of natural and socioeconomic factors, coastal areas have ...
R. Susman, Annelie M. Gütte, Thomas Weith   +2 more
semanticscholar   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source