Results 121 to 130 of about 12,143,613 (336)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
TRANSCENDING THE TRAJECTORY OF CYCLICAL IMPASSE: IN SEARCH OF A NEW BEGINNING IN ESIABA IROBI’S NWOKEDI [PDF]
Diversitate si Identitate Culturala in Europa, 2013 Arguably, Nigeria’s transition from the military regime to the democratic rule in 1999 only marginally altered its political context dramatically. Nevertheless, corruption and mismanagement of her economic potential portentously remain her abiding ...
NIYI AKINGBE
doaj
Frontiers in Psychology, 2012 Common wisdom in the field of human vision suggests that top-down selective attention is required in order to bind features into objects. Without selective attention, presumably we are unable even to distinguish such simple stimuli as a rotated T vs.
Ruth eRosenholtz +3 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Moving towards Adaptive Search [PDF]
, 2009 Information retrieval has become very popular over the last decade with the advent of the Web. Nevertheless, searching on the Web is very different to searching on smaller, often more structured collections such as intranets and digital libraries.
De Roeck, A +5 more
core
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Search conversion journeys and the missed opportunity of associated keywords
Frontiers in CommunicationWe map the conversion journey (i.e., the path a costumer takes to purchase a product or service) for phones, laptops, and vehicles (i.e., cars and trucks) by analyzing a massive corpus of online searches on Bing by people in the U.S. during 2021. We show
David M. Rothschild +3 more
doaj +1 more source
COMPUTER SEARCH VERSUS TECHNICAL-SCIENTIFIC FINDING [PDF]
Challenges of the Knowledge Society, 2018 The study intends to establish delimitation between computer search and technical-scientific finding, having as a starting point certain cases encountered in the judicial practice when the law enforcement authorities confused the scopes of these two ...
Radu SLĂVOIU
doaj
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source