Results 91 to 100 of about 286,493 (314)
, 2019 Application programming interfaces, or APIs, have been the topic of much recent discussion. Newsworthy events, including those involving Facebook’s API and Cambridge Analytica obtaining information about millions of Facebook users, have highlighted the ...
Russell, N. Cameron
core +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Graph Analytics on Manycore Memory Systems
IEEE Access, 2018 Graphs are ubiquitous, and graph analytics has been widely adopted in many big data applications such as social computation and natural language processing, as well as web-search and recommendation systems.
Yuxuan Xing +4 more
doaj +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
ACROSSAnalytics and AI innovations have the potential to help the decision-making processes and to bring more business opportunities for stakeholders. This study explored how analytics and AI support decision-making in EdTech platforms.
Marian STAN +2 more
doaj +2 more sources
Guided Text Search Using Adaptive Visual Analytics [PDF]
, 2012 This research demonstrates the promise of augmenting interactive visualizations with semi- supervised machine learning techniques to improve the discovery of significant associations and insights in the search and analysis of textual information. More specifically, we have developed a system called Gryffin that hosts a unique collection of techniques ...
Steed, Chad A +3 more
openaire +2 more sources
Molecular Oncology, EarlyView.A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira +14 more
wiley +1 more source
Modern Internet Search Analytics and Osseointegration: What are Patients Asking and Reading Online? [PDF]
Strategies Trauma Limb Reconstr, 2023 Murphy EP +6 more
europepmc +1 more source