Results 71 to 80 of about 233,817 (274)
Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target
FEBS Letters, EarlyView.This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz +5 more
wiley +1 more source
An advanced search engine for patent analytics in medicinal chemistry [PDF]
, 2012 Patent collections contain an important amount of medical-related knowledge, but existing tools were reported to lack of useful functionalities. We present here the development of TWINC, an advanced search engine dedicated to patent retrieval in the domain of health and life sciences.
Pasche, Emilie +6 more
openaire +4 more sources
HELIN Data Analytics Task Force Final Report [PDF]
, 2015 The main task undertaken by the HELIN Data Analytics Task Force was to conduct a proof-of-concept usability test of HELIN OneSearch, which is the Consortium’s brand name for the Encore Duet discovery service.
HELIN Consortium. Data Analytics Task Force
core +1 more source
Data-driven Job Search Engine Using Skills and Company Attribute Filters
, 2017 According to a report online, more than 200 million unique users search for jobs online every month. This incredibly large and fast growing demand has enticed software giants such as Google and Facebook to enter this space, which was previously dominated
Gao, Hua +5 more
core +1 more source
FEBS Letters, EarlyView.Angiotensin II (AngII), a neuropeptide, interacts with amyloid‐β (Aβ), a key player in Alzheimer's disease. This study reveals that AngII reduces Aβ aggregation and membrane disruption in vitro. Biophysical assays and molecular modeling suggest AngII binds disordered Aβ forms, potentially modulating early amyloidogenic events and contributing to ...
Mohsen Habibnia +5 more
wiley +1 more source
A Fuzzy TOPSIS Approach for Big Data Analytics Platform Selection [PDF]
Journal of Advances in Computer Engineering and Technology, 2019 Big data sizes are constantly increasing. Big data analytics is where advanced analytic techniques are applied on big data sets. Analytics based on large data samples reveals and leverages business change.
Salah Uddin +4 more
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Data Science and Analytics in Libraries
Mitteilungen der Vereinigung Österreichischer Bibliothekarinnen und Bibliothekare, 2017 Libraries have the virtue of managing vast amounts of information. Data Science and Analytics techniques and methodologies allow libraries to fully exploit the content they hold with the goal of providing better information to their users: better search,
José Luis Preza
doaj +1 more source
FEBS Letters, EarlyView.Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer +7 more
wiley +1 more source
FEBS Letters, EarlyView.Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur +5 more
wiley +1 more source
Associative Analysis in Statistics [PDF]
Revista Română de Statistică, 2015 In the last years, the interest in technologies such as in-memory analytics and associative search has increased. This paper explores how you can use in-memory analytics and an associative model in statistics.
Mihaela Muntean
doaj