Results 81 to 90 of about 736,923 (337)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

open access: yesMolecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir   +12 more
wiley   +1 more source

Linnaeus builds a search engine

open access: yesEuropean Journal of Taxonomy
Botanists and zoologists in the 18th Century faced an explosion of species. What they needed was the equivalent of a search engine, and Carl Linnaeus rose to the challenge.
Mary P. Winsor
doaj   +1 more source

Towards Question on Linguistic Approach to Search Engine Optimization: Clustering, Collocation, Grams

open access: yesSHS Web of Conferences, 2018
The article is devoted to the problem of search engine optimization in the context of nowadays reality. Linguistics can become one of the main instruments to improve its marketing position of the web-product so the linguistic approach to the search ...
Akay Oksana   +3 more
doaj   +1 more source

Transcriptional regulation of neuropeptide receptors underlies context‐dependent adaptation in Drosophila melanogaster

open access: yesFEBS Open Bio, EarlyView.
Under environmental changes, the expression level of neuropeptide (NP) and neuropeptide receptor (NPR) genes changes to confer context‐dependent adaptation to the model organism Drosophila melanogaster. Through finding more regulatory elements in the NPR genes in comparison with their ligands (NPs), we found that NPR‐biased transcriptional regulation ...
SeungHeui Ryu   +6 more
wiley   +1 more source

Structural and functional characterization of chitinase from carnivorous plant Drosera adelae

open access: yesFEBS Open Bio, EarlyView.
A class I chitinase from the carnivorous plant Drosera adelae was expressed and purified using a yeast system, revealing high enzymatic activity. Structural analyses of the catalytic and chitin‐binding domains identified key tyrosine residues involved in substrate binding, offering insights into the enzyme's adaptation for insect digestion.
Kazunari Yoneda   +7 more
wiley   +1 more source

Search Engine Bias and the Demise of Search Engine Utopianism [PDF]

open access: yes, 2008
Due to search engines’ automated operations, people often assume that search engines display search results neutrally and without bias. However, this perception is mistaken. Like any other media company, search engines affirmatively control their users’ experiences, which has the consequence of skewing search results (a phenomenon called “search engine
openaire   +2 more sources

Structural and functional analysis of Bacillus sarcosine oxidase and its activity toward cyclic imino acids

open access: yesFEBS Open Bio, EarlyView.
Sarcosine oxidase from Bacillus sp. (SoxB) recognizes l‐proline (l‐Pro), d‐proline (d‐Pro), and l‐thioproline (l‐Tpr) as minor substrates. In this study, we measured their absorption spectra, determined the crystal structures of their enzyme complexes, and performed site‐directed mutagenesis of key residues.
Yuqi Zhang   +5 more
wiley   +1 more source

Quantification of competitive value of documents

open access: yesActa Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2009
The majority of Internet users use the global network to search for different information using fulltext search engines such as Google, Yahoo!, or Seznam.
Pavel Šimek   +2 more
doaj   +1 more source

Card games are effective tools to enhance foundation year health and safety inductions

open access: yesFEBS Open Bio, EarlyView.
A series of three card games was developed to actively deliver health and safety education to foundation year students. Most students reported positive responses regarding their enjoyment (89.9 %) and learning (74.7 %) from all games evaluated. Data revealed significant improvements in health and safety knowledge (P < 0.0001).
Rumana Rafiq   +4 more
wiley   +1 more source

Study and Applying of Search Engine Technique in Mobile Internet Music

open access: yesDianxin kexue, 2015
The music business of China Telecom have high performance, more reasonable precision ratio and recall ratio, timeliness of indexing and other needs in music search to meet the requirements for mobile internet users.
Yiping Yang   +3 more
doaj   +2 more sources

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