Results 71 to 80 of about 4,165,412 (300)
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
A Model of Optimal Network Structure for Decentralized Nearest Neighbor Search
, 2017 One of the approaches for the nearest neighbor search problem is to build a network which nodes correspond to the given set of indexed objects. In this case the search of the closest object can be thought as a search of a node in a network.
Batsyn, Mikhail +2 more
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Application of pattern search method to power system valve-point economic load dispatch
, 2007 Direct search (DS) methods are evolutionary algorithms used to solve constrained optimization problems. DS methods do not require any information about the gradient of the objective function at hand, while searching for an optimum solution.
AL-Othman, A.K. +2 more
core +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Experimental search for drugs for the treatment of atrial fibrillation (literature review)
Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровьеAtrial fibrillation is the most common cardiac arrhythmia with frequent complications. Despite a century of research and speculation, the mechanisms underlying AF have not been fully elucidated, and therapy, especially for the permanent form, remains ...
A. A. Abdullaev +8 more
doaj +1 more source
Wilderness in 19th Century South Seas Literature: An Ecocritical Search for Seascapes
eTropic: electronic journal of studies in the tropics, 2022 In Western thought and literature, a terrestrial bias is considered a phenomenological primacy for notions such as wilderness. This ecocritical review draws on nineteenth-century South Seas literature with its influences from frontierism and the ...
Denise Dillon
doaj
Yod, 2009 This article engages with Amos Gitai’s personal interpretation of Ya’akov Shabtai’s novel, Past Continuous (Zikhron Dvarim). For many years no one had dared to adapt this most modernistic novel to the screen, until filmmaker Gitai decided that his return
Yael Munk
doaj +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source