The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Adolescents’ academic achievement and meaning in life: the role of self-concept clarity
Frontiers in PsychologySense of meaning in life is closely related to adolescents’ well-being. While prior research has largely examined the effects of individual traits and environmental influences, adolescents’ personal experiences (e.g., academic achievement) also play a ...
Fang Liu +4 more
doaj +1 more source
Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers
FEBS Letters, EarlyView.Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui +4 more
wiley +1 more source
Memorial March Discussion, 1969
, 1969 Members Memphis Search for Meaning Committee and their younger children discuss their observations about the events surrounding various marches in ...
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Exploring travel and spirituality: The role of travel in facilitating life purpose and meaning within the lives of individuals [PDF]
, 2010 This thesis is a phenomenological study of individuals who engaged in tours provided by Hands Up Holidays, a tour operator marketing their travel as ‘spiritual’.
Willson, Gregory Brian +1 more
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A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Gratitude and life satisfaction among Filipino adolescents: The mediating role of meaning in life
, 2015 The current research assesses the mediating effects of meaning in life on the relationship between gratitude and life satisfaction. A sample of Filipino college students (N = 409) in a private sectarian university completed the Gratitude Questionnaire ...
Mateo, Nino Jose +2 more
core +1 more source
Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis
FEBS Letters, EarlyView.This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng +8 more
wiley +1 more source
Pondering Purpose: The Search for Meaning in Life as Motivated Social Cognition [PDF]
, 2014 The search for meaning in life has been considered a fundamental human motivation (Frankl, 1963). Although research has pointed toward the importance of the search for meaning in life, the basic processes through which it emerges remain unclear.
Vazeou-Nieuwenhuis, Anna
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How the search for meaning in life affects reactions to brand extensions
, 2023 My dissertation assesses the effect of the search for meaning in life on consumer evaluations of brand extensions. Results from six studies demonstrate that for high hedonic brand extensions, consumers who are searching for meaning in life (vs.
core +1 more source