Results 51 to 60 of about 3,504 (168)

Patient‐Derived IgG Epitope Mapping of Bet v 1 Reveals Hypoallergenic Peptide Candidates for Safe and Next‐Generation Allergen Immunotherapy

Clinical &Experimental Allergy, Volume 56, Issue 8, Page 881-892, August 2026.
Mapping IgG epitopes of the major birch allergen Bet v 1 identified patient‐derived, hypoallergenic peptides that did not trigger degranulation. These findings support a novel, safer approach for peptide‐based allergen immunotherapy that leverages naturally induced IgG specificities from allergic individuals. ABSTRACT Background Allergen immunotherapy (
Lara Šošić, Marta Paolucci, Alessandro Streuli, David A. Melillo, Tianchi Jiang, Raffaela Campana, Claudia C. V. Lang, Thomas M. Kündig, Christian Steuer, Klaus Eyer, Pål Johansen   +10 more
wiley   +1 more source

Efficacy and tolerability comparison of olopatadine, ketotifen, and epinastine in seasonal allergic conjunctivitis: A prospective open-label comparative study

National Journal of Physiology, Pharmacy and Pharmacology, 2019
Background: Seasonal allergic conjunctivitis (SAC) is the most common allergic disease affecting the eye, with an estimated prevalence of 15–20%.
Anusha S J, Jyothi R, Umadevi R S, Girish K   +3 more
doaj   +1 more source

Risk of injury associated with the sedative potential of second‐generation antihistamines: A nationwide retrospective cohort study

British Journal of Clinical Pharmacology, Volume 92, Issue 7, Page 2230-2238, July 2026.
Abstract Aim Individual second‐generation antihistamines may possess differential sedative potential due to the variability in central histamine receptor H1 occupancy. This study aimed to evaluate whether the sedative potential of second‐generation antihistamines is associated with the risk of injury during Japan's pollen season. Methods We conducted a
Jumpei Taniguchi, Shotaro Aso, So Sato, Hideo Yasunaga   +3 more
wiley   +1 more source

Clinical characteristics of allergic conjunctivitis in the Southern region of Saudi Arabia: a cross-sectional study

Therapeutic Advances in Ophthalmology
Background: Allergic conjunctivitis is a prevalent ocular condition characterized by inflammation of the conjunctiva due to hypersensitivity reactions to various allergens.
Waleed ALDhabaan, Saleh Ghulaysi, Albatool Alqahtani, Eman Hurissi, Manar M. Alamri, Almuhannad G. Alnami, Ahmed H. Sumayli, Yahya A. Dhamri, Amani A. Mosleh, Ethar A. Khawaji, Abdullah A. Alshahrani, Abdulsalam S. Alfaifi, Saja M. Alghamdi   +12 more
doaj   +1 more source

Comparative Evaluation of the Efficacy in Treating Children with Seasonal Allergic Rhinitis Using Antihistamine Combined with Ectoine Nasal Spray and Antihistamine Monotherapy: Results of an Open Randomized Study

Вопросы современной педиатрии, 2015
Objective: Our aim was to evaluate the efficacy of an ectoine nasal spray in treating children with seasonal allergic rhinitis.Methods: An open randomized study of children aged 3–17 with the aggravation of early spring hay fever.
N. V. Minaeva, D. M. Shiryaeva
doaj   +1 more source

Efficacy and safety of ketotifen eye drops in the treatment of seasonal allergic conjunctivitis [PDF]

British Journal of Ophthalmology, 2003
Ketotifen blocks histamine H(1) receptors, stabilises mast cells, and prevents eosinophil accumulation. These multiple, pharmacological mechanisms provided the rationale for assessing the efficacy and safety of ketotifen 0.025% eye drops in subjects with seasonal allergic conjunctivitis (SAC) in an environmental setting.This was a double masked ...
Kidd, M., McKenzie, S.H., Steven, I., Cooper, C., Lanz, R., Australian Ketotifen Study Group   +5 more
openaire   +3 more sources

In‐Hospital Complications of Influenza A and B Among Hospitalized Australian Children in the Post‐COVID Era

The Clinical Respiratory Journal, Volume 20, Issue 7, July 2026.
In the post‐COVID‐19 Australian pediatric cohort of 704 hospitalizations, influenza B accounted for one‐third of cases but was associated with greater severity than influenza A. Children with influenza B had higher risks of noninvasive respiratory support and intensive care unit admission and/or mechanical ventilation, particularly among those aged 5 ...
Angelica Wei Wen Hii, Jahidur Rahman Khan, Kishor Kumar Paul, Mei Chan, Nan Hu, Brendan McMullan, Philip N. Britton, Adam W. Bartlett, Rama Kandasamy, Louisa Owens, Bernadette Prentice, Adam Jaffe, Nusrat Homaira   +12 more
wiley   +1 more source

Local Specific IgE Levels Can Predict and Monitor the Therapeutic Response to Subcutaneous Immunotherapy With House Dust Mite

International Forum of Allergy &Rhinology, Volume 16, Issue 6, Page 561-571, June 2026.
ABSTRACT Background Identifying predictive and monitoring biomarkers for allergen immunotherapy response is crucial for enhancing clinical efficacy. This study aims to investigate the systemic and local levels of immunoglobulins and identify potential biomarkers in house dust mite (HDM) allergic rhinitis (AR) patients who are undergoing subcutaneous ...
Xu Xu, Jingyun Li, Xu Zhang, Yu Song, Lin Xi, Luo Zhang, Yuan Zhang   +6 more
wiley   +1 more source

GWAS of Second‐Generation Antihistamine Use: Locus Specificity and Highlighted Signalling Pathways

Clinical &Experimental Allergy, EarlyView.
M. Niemi, S. Ruotsalainen, E. Saarentaus, I. Vähätalo, F. FinnGen, I. Starskaia, T. Harju, M. Pelkonen, T. Feuth, P. Kauppi, J. Partanen, R. Lahesmaa, V. Hytönen, A. Palotie, H. Kankaanranta, T. Laitinen   +15 more
wiley   +1 more source

Update and clinical utility of alcaftadine ophthalmic solution 0.25% in the treatment of allergic conjunctivitis

Clinical Ophthalmology, 2015
DeGaulle I Chigbu, Alissa M Coyne Pennsylvania College of Optometry Salus University, Elkins Park, PA, USA Abstract: Allergic disorders of the ocular surface are primarily characterized as IgE- and/or T-lymphocyte-mediated disorders that affect ...
Chigbu DI, Coyne AM
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