Results 131 to 140 of about 21,412 (280)

Mechanisms of Aristolochic Acid Resistance in Specialist Butterflies and Evolutionary Insights for Potential Protective Pathways

Advanced Science, EarlyView.
The study provides an extreme example of insect adaptation to highly toxic defenses of host plants, and investigates the complex strategies to resist carcinogenic aristolochic acids, including physical isolation, metabolic detoxification, and DNA repair.
Yang Luan, Yubo Zhang, Jingjing Li, Jianqing Zhu, Yuyang Lei, Yushi Hu, Zhenqiang Xin, Tianpei Xie, Jiang Zheng, Yuanyuan Lin, Jingjing Shen, Yiyi Cao, Xinyue You, Jing Xi, Jiaying Wu, Weiying Liu, Xinyu Zhang, Yuanting Zheng, David J. Lohman, Leming Shi, Wei Zhang   +20 more
wiley   +1 more source

Microgel‐Based Hierarchical Porous Hydrogel Patch with Adhesion and Resilience for Myocardial Infarction

Advanced Science, EarlyView.
This study develops a hierarchically porous hydrogel patch strategy (HPMP), based on gas‐shearing microfluidics and an aqueous two‐phase system to fabricate porous microgels as microgel‐based bioinks. The porous microgels with controllable porous structure exhibit excellent cellular behavior.
Ziyang Liu, Leyan Xuan, Yingying Hou, Ting Xie, Jieting Li, Junjie Cai, Siyu Zhang, Yingling Miao, Ning Hou, Gen He, Maobin Xie, Xiyong Yu, Mingen Xu, Guosheng Tang   +13 more
wiley   +1 more source

Targeted Mitochondrial ECSIT Overexpression Attenuates MASH by Increasing OTUD3 Expression

Advanced Science, EarlyView.
Mitochondrial ECSIT expression is reduced during MASH pathogenesis. Overexpression of mitochondrial ECSIT mitigates steatohepatitis and maintains hepatic metabolic homeostasis. Mechanistically, ECSIT enhances intramitochondrial OTUD3 expression to stabilize SIRT3 through deubiquitination, thus preserving mitochondrial function and impeding disease ...
Yuqing Jiang, Tingting Tong, Pengxi Shi, Xiaofan Chen, Chenhao Wang, Qingyuan Weng, Sihan Chen, Linli Que, Qi Chen, Yuehua Li, Qiang Zhu, Jiantao Li   +11 more
wiley   +1 more source

بررسی پتانسيل نئوپلازی خال سباسه [PDF]

, 2004
خال سباسه(Jadassohn) هامارتومی است که ترکيبی از ناهنجاری‌های اپيدرمال و غدد آپوکرين، سباسه و فوليکولار می‌باشد. به طور کلاسيک، چندين نوع نئوپلازی خوش خيم و بدخيم جلدی، با اين هامارتوما در ارتباط می‌باشند.
تکليف, ماه جبین, جليلوند, احمد   +1 more
core  

A case of orbital sebaceous gland carcinoma developing in an anophthalmic socket 65 years after enucleation

Clinical Ophthalmology, 2013
Motoko Shibata,1,* Yoshihiko Usui,1,* Shunichiro Ueda,1 Hajime Matsumura,2 Toshitaka Nagao,3 Hiroshi Goto1 1Department of Ophthalmology, 2Department of Plastic and Reconstructive Surgery, 3Department of Anatomic Pathology, Tokyo Medical University, Tokyo,
Shibata M, Usui Y, Ueda S, Matsumura H, Nagao T, Goto H   +5 more
doaj  

Liver Stiffness Rises Early in MASLD and Drives Inflammation, Lipid Dysmetabolism, and Fibrosis via Piezo1–YAP Mechanotransduction

Advanced Science, EarlyView.
Progressive stiffening of the hepatic extracellular matrix and free fatty acid overload activate the mechanosensor Piezo1 in steatotic hepatocytes, inducing calcium influx and nuclear translocation of Yes‐associated protein. YAP‐dependent nuclear signaling further drives inflammatory and fibrotic gene programs, lipid metabolic reprogramming, and ...
Juan Ma, Ning Xie, Ziwei Wang, Xiru Liang, Yulong Han, Qiang Zhao, Ming Wang, Hongwei Lu, Wanyi Kou, William Alazawi, Jinhai Wang, Lu Li, Ning Liu, Na Liu, Haitao Shi, Feng Xu   +15 more
wiley   +1 more source

Localization of steroid hormone receptors in the apocrine sweat glands of the human axilla [PDF]

, 2018
The apocrine axillary glands, regarded as pheromone-producing scent glands, do not begin to function until puberty. Accordingly, sex hormones should have an impact on their activity, and the present study was designed to investigate the localization of ...
Beier, Konstantin, Ginez, Isabelle, Schaller, Heidi   +2 more
core  

Xanthatin Targets CISD1 to Drive Ferroptosis and Mitophagy as a Dual Anticancer Strategy in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Triple‐negative breast cancer has a poor prognosis. Xanthatin directly targets and degrades CISD1, triggering ferroptosis through iron dysregulation. The concurrently activated mitophagy synergistically amplifies ferroptotic cell death. Xanthatin also demonstrates potent in vivo anti‐tumor efficacy with minimal toxicity, highlighting its therapeutic ...
Qinwen Liu, Haojie Chen, Xiang Li, Jingxin Liu, Yiwen Li, Zhenyi Shi, Shenshen Guo, Qingfeng Du, Aiping Lu, Daogang Guan   +9 more
wiley   +1 more source

Curious Case of Swelling over the Back: A Case Report of Sebaceous Cell Carcinoma in a Patient of Airborne Contact Dermatitis

Clinical Dermatology Review
Sebaceous carcinoma is a rare variety of malignant tumor involving sebaceous glands. Compared to its ocular counterpart, the extraocular variant is even more rare, accounting for only one-fourth of all cases.
Sonia Jain, Sangeeta Galui, Pratiksha Sonkusale   +2 more
doaj   +1 more source

Beyond Transconductance: Cell‐Polymer Coupling Determines Fidelity in Action Potential Recording via Electrolyte‐Gated Polymer Transistors

Advanced Science, EarlyView.
High electrical performance alone does not guarantee efficient bioelectronic signal transduction. Despite excellent mixed ionic‐electronic conduction, recordings from cardiomyocytes reveal that p(g2T‐TT)‐based OECTs predominantly transduce field potential FP‐like signals due to weak cell‐polymer coupling.
Giulia Zoe Zemignani, Elena Mancinelli, Gabriele Tullii, Aleksandr Khudiakov, Cristiano Bortolotti, Shubham Tanwar, Peter J. Schwartz, Luca Sala, Maria Rosa Antognazza, Mario Caironi, Adrica Kyndiah   +10 more
wiley   +1 more source