Results 101 to 110 of about 18,276 (243)

Four Different Tumors Arising in a Nevus Sebaceous

Case Reports in Dermatology, 2016
Nevus sebaceous is known by its association with one or more secondary tumors, but more than three multiple tumors arising from a nevus sebaceous is extremely rare.
Takeshi Namiki, Keiko Miura, Makiko Ueno, Yumi Arima, Aya Nishizawa, Hiroo Yokozeki   +5 more
doaj   +1 more source

Keratinocyte Stem Cells: friends and foes [PDF]

, 2010
Skin and its appendages provide a protective barrier against the assaults of the environment. To perform its role, epidermis undergoes an ongoing renewal through a balance of proliferation and differentiation/apoptosis called homeostasis.
Alonso, Barrandon, Blanpain, Blanpain, Botchkarev, Braun, Chao, Charruyer, Chiarugi, Clayton, Coolen, Cotsarelis, Dallaglio, Espada, Ferreira, Franssen, Fuchs, Fuchs, Ghazizadeh, Ghazizadeh, Giangreco, Grabe, Harper, Horsley, Inoue, Jaks, Janes, Jensen, Jensen, Jensen, Jones, Jones, Kim, Kim, Klein, Legg, Lena, Levy, Li, Liefer, Lindner, Lippens, Lo Muzio, Lotti, Manohar, Marconi, Marconi, Marconi, Medawar, Mita, Mitra, Morris, Muffler, Nijhof, Pellegrini, Piwko-Czuchra, Qin, Savoia, Schneider, Senoo, Snippert, Sotiropoulou, Sotiropoulou, Tiberio, Tiede, Titeux, Trempus, Trempus, Tudor, Wang, Watt, Yi, Youssef, Yu, Zhan, Zhang, Zhang   +76 more
core   +1 more source

p16Ink4a‐Positive Hepatocytes Drive Liver Fibrosis Through Activation of LIFR Family Pathway

Advanced Science, EarlyView.
This study found that, following the long‐term CCl4 treatment, p16high hepatocytes appeared in zone 3, spatially co‐localizing with fibrotic areas. A specific cluster of p16high hepatocytes upregulated CTF1/LIF expression which induced HSC activation and further liver fibrosis, as revealed by single cell transcriptomic analysis.
Koji Nishikawa, Teh‐Wei Wang, Satoshi Kawakami, Shota Tanimoto, Kiyoshi Yamaguchi, Taketomo Kido, Masamichi Kimura, Tsunekazu Hishima, Yuki T. Okamura, Satotaka Omori, Takumi Iritani, Toshikaze Chiba, Takehiro Jimbo, Michio Katano, Kansuporn Kamataki, Ryoichi Yokoyama, Eigo Shimizu, Kiminori Kimura, Satoshi Yamzaki, Seiya Imoto, Yoichi Furukawa, Atsushi Miyajima, Yoshikazu Johmura, Makoto Nakanishi   +23 more
wiley   +1 more source

Characterizing Stage‐Specific Cellular Dynamics and Microenvironmental Remodeling in Lung Adenocarcinoma by Single‐Cell RNA Sequencing

Advanced Science, EarlyView.
This study integrated early‐stage patient specimens with publicly available datasets encompassing non‐malignant lung tissues and advanced‐stage LUAD through single‐cell sequencing, revealing a dynamically remodeled tumor microenvironment characterized by a hypoxia‐adapted malignant subset (C5), immunosuppressive LGMN+ macrophages, STAT1‐driven ...
Bomiao Qing, Xiaolan Li, Xiang He, Junyi Wang, Yi Yang, Manling Jiang, Bingbing Yan, Lei Zhang, Anying Xiong, Qin Ran, Guoping Li   +10 more
wiley   +1 more source

A case of orbital sebaceous gland carcinoma developing in an anophthalmic socket 65 years after enucleation

Clinical Ophthalmology, 2013
Motoko Shibata,1,* Yoshihiko Usui,1,* Shunichiro Ueda,1 Hajime Matsumura,2 Toshitaka Nagao,3 Hiroshi Goto1 1Department of Ophthalmology, 2Department of Plastic and Reconstructive Surgery, 3Department of Anatomic Pathology, Tokyo Medical University, Tokyo,
Shibata M, Usui Y, Ueda S, Matsumura H, Nagao T, Goto H   +5 more
doaj  

Hepatocyte Mettl3 Deficiency Drives Primary Sclerosing Cholangitis and Liver Fibrosis via Cholangiocyte‐Macrophage Crosstalk

Advanced Science, EarlyView.
Schematic illustration demonstrating that hepatic Mettl3 depletion significantly elevates the secretion of Mif and Csf1. This elevation facilitates Trem2+ macrophage infiltration and triggers cholangiocyte remodeling through the Spp1‐Cd44 interaction, resulting in spontaneous PSC development in vivo.
Wenting Pan, Yuting Yong, Yuanshuai Li, Gaona Shi, Min Zhang, Lingfei Wan, Yue Zhao, Wenling Zhan, Yanli Lin, Qiaozhen Qin, Xupeng Chen, Yanli Ni, Haixu Chen, Wenzai Shi, Xiaomeng Guo, Juan Chen, Shuchen Liu, Youliang Wang, Bing Liu, Xinlong Yan   +19 more
wiley   +1 more source

Incidence and prevalence of salivary gland tumours in Valparaiso, Chile [PDF]

, 2015
Background : To determine the incidence and prevalence of salivary gland tumours in the province of Valparaíso, Chile. Material and Methods : Retrospective review of salivary gland tumours diagnosed between the years 2000 and 2011 from four
Araya, Juan, Esguep, Alfredo, Marshall, Maureen, Martínez, René, Niklander, Sven   +4 more
core   +2 more sources

Disrupting the Formation of YAP Condensates Promotes the Activation of AMPKα to Inhibit the Progression of Primary Liver Cancer

Advanced Science, EarlyView.
This study systematically investigates the function and molecular mechanisms of YAP phase separation in multiple primary liver cancers. These findings provide novel insights into phase separation‐mediated primary liver cancer development and validate targeted disruption of this process as an effective therapeutic strategy for primary liver cancer ...
Shuang‐Zhou Peng, Jia‐Jia Liang, Yun‐Feng Zhan, Wei‐Xun Wu, Wan‐Li Xu, Xiao‐Kun Zhang, Li‐Jun Cai, Fu‐Quan Jiang   +7 more
wiley   +1 more source

Squamous cell carcinoma and basal cell carcinoma arising from a nevus sebaceous

Skin Cancer, 2005
58歳, 男性。幼少時より右側頭部に常色の局面があり, 同部に大小の腫瘤が出現してきた。病理組織学的に, 有棘細胞癌と基底細胞癌と診断, 常色の局面は脂腺母斑であった。手術的に摘出し, いずれも再発転移なく経過している。脂腺母斑から二次発生する腫瘍の病理組織診断につき, 文献的に考察した。
Toshihiro TAKAI, Akiko MATSUNAGA, Byung-Kwi CHUNG, Toshinori BITO, Masato VEDA, Masamitsu ICHIHASHI   +5 more
openaire   +2 more sources

ERM Inhibition Confers Ferroptosis Resistance through ROS‐Induced NRF2 Signaling

Advanced Science, EarlyView.
ERM inhibition disrupts ERM‐actin interactions, elevating ROS and triggering KEAP1 degradation, which stabilizes and activates NRF2. Nuclear NRF2 induces cytoprotective genes, notably HMOX1, enhancing redox buffering and suppressing lipid peroxidation to resist erastin‐induced ferroptosis.
Menghao Qiao, Liqun Zhou, Minhua Zhou, Yu Fang, Haiying Mai, Lingbo Cao, Kun Xu, Yuan Sang, Minyi Chen, Jiewei Huang, Peiyi Huang, Zhipeng Yan, Chao Wang, Zhangshuai Dai, Dichun Huang, Ronghan He, Lijuan Pang, Yunmiao Guo, Ting Gang Chew, Junqi Huang   +19 more
wiley   +1 more source