Results 111 to 120 of about 18,276 (243)

Coexisting Basal Cell Carcinoma and Squamous Cell Carcinoma in Congenital Nevus Sebaceous

SKIN The Journal of Cutaneous Medicine, 2018
Nevus sebaceous is a congenital epidermal hamartoma characterized by hyperplastic changes to the epidermis and adnexa. Nevus sebaceous is associated with an elevated risk of cutaneous neoplasms, most often benign; however, malignant neoplasms, most notably basal cell carcinoma, can also present in these patients.
Jordan Rosen, Katherine Nolan, Noah Shaikh, Les Rosen, Martin Zaiac   +4 more
openaire   +1 more source

Endocytic Control of Cell‐Autonomous and Non‐Cell‐Autonomous Functions of p53

Advanced Science, EarlyView.
NUMB Ex3‐containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells and activates nuclear programs, revealing an intercellular, exosome‐based pathway that might help establish a tumor‐suppressive microenvironment.
Roberta Cacciatore, Andrea Basile, Stefano Freddi, Irene Schiano Lomoriello, Carlo Ribelle Zucca, Giuseppe Ciossani, Luigi Scietti, Alessandro Cuomo, Simona Ronzoni, Simone Pelicci, Mario Faretta, Elena Zaccheroni, Giuliana Pelicci, Vittoria Matafora, Angela Bachi, Rosalind Helen Gunby, Salvatore Pece, Sara Sigismund, Letizia Lanzetti, Ivan Nicola Colaluca, Pier Paolo Di Fiore   +20 more
wiley   +1 more source

Eyelid Squamous Cell Carcinoma in a Dog [PDF]

, 2012
A 10-year-old, female, Yorkshire Terrier was presented with a left lower eyelid mass. No other abnormality was detected on affected eye in a general eye examination.
Chang-hyun Song1§, Sae-kwang Ku2§, Hwan-soo Jang3, Eun-young Kye, Sung-ho Yun, Kwang-ho Jang and Young-sam Kwon*
core  

Characterization of hair-follicle side population cells in mouse epidermis and skin tumors. [PDF]

, 2017
A subset of cells, termed side-population (SP), which have the ability to efflux Hoeschst 33342, have previously been demonstrated to act as a potential method to isolate stem cells. Numerous stem/progenitor cells have been localized in different regions
Kim, S.H., Miliani de Marval, P.L., Rodriguez-Puebla, M.L., Sistrunk, C.   +3 more
core   +1 more source

Autocrine Netrin‐1 Signaling in Hepatic Stellate Cells Drives Liver Fibrosis and Diet‐Induced Metabolic Dysfunction‐Associated Steatohepatitis in Mice

Advanced Science, EarlyView.
Netrin‐1 expression is upregulated in hepatic stellate cells (HSCs) during metabolic dysfunction–associated steatohepatitis and injury‐mediated liver fibrosis. Secreted Netrin‐1 establishes an autocrine positive feedback loop by binding to UNC5B receptors on HSCs.
Jiahui Zhao, Yajie Peng, Hongyan Lei, Tianyi Wang, Huajuan Wang, Bo Wang, Jin Li, Xiaoying Li, Xuelian Xiong   +8 more
wiley   +1 more source

Papular lesion occurring within a longstanding warty plaque, in skin of colour Fitzpatrick type 4–5

Skin Health and Disease
A 23‐year‐old man of South Asian descent, Fitzpatrick type 4–5 skin, usually fit and well, presented with a 6‐month history of a darkly‐pigmented papular lesion growing within a pre‐existing warty plaque on the left parietal scalp, present since birth ...
Joelle Teoh, Alex Gan, Joshua Ramalingam, Somaia Elsheikh, Richard Jerrom   +4 more
doaj   +1 more source

Identification of Associations with Dermatologic Diseases through a Focused GWAS of the UK Biobank

JID Innovations
The UK Biobank includes genotype information for about 500,000 patients for over 7000 phenotypes. However, owing to multiple testing correction for approximately 200 billion tests, many clinically and statistically significant associations remain ...
Jason C. Klein, Ruchika Mahapatra, Gary C. Hon, Richard C. Wang   +3 more
doaj   +1 more source

Considerations for skin carcinogenesis experiments using inducible transgenic mouse models. [PDF]

, 2018
OBJECTIVE: This study was designed to estimate the percentage of non-malignant skin tumours (papillomas) progressing to malignant squamous cell carcinomas (SCCs) in a carcinogenesis study using established transgenic mouse models.
Blanco, Sandra, Constantino-Casas, Fernando, Frye, Michaela, Popis, Martyna C, Wagner, Rebecca E   +4 more
core   +1 more source

NuSAP Safeguards Centriole Integrity to Mediate CEP57‐CEP152 Torus Recruitment for Proper Engagement

Advanced Science, EarlyView.
This study reveals a novel role for the microtubule stabilizer NuSAP at centrioles. NuSAP depletion destabilizes the centriole's tubulin structure, causing premature disengagement, PCM defects, and mis‐localization of the CEP57‐CEP63‐CEP152 complex. By reinforcing centriole architecture, NuSAP enables early CEP57 loading and initiates a newly proposed ...
Shiyu Zhang, Zemin Jiang, Qiaoyun Yang, Hong Zheng, Minghao Wang, Chennianci Zhu, Lih‐Wen Deng, Karen Carmelina Crasta, Yih‐Cherng Liou   +8 more
wiley   +1 more source

Syringocystadenoma Papilliferum and Basal Cell Carcinoma Arising in Nevus Sebaceous

Clinical, Cosmetic and Investigational Dermatology, 2022
Jingjing Jiang *, Yujuan Chen *, Qi He, Jiao Yang, Zhengzhong Zhang, Hao Yang, Huan Zhang, Chuan Yang Department of Dermatology, Affiliated Hospital of North Sichuan Medical College, Nanchong, People’s Republic of China*These authors ...
Jiang J, Chen Y, He Q, Yang J, Zhang Z, Yang H, Zhang H, Yang C   +7 more
doaj