Results 1 to 10 of about 32,315 (109)

Exploring the ER channel protein Sec61: recent advances in pathophysiological significance and novel pharmacological inhibitors [PDF]

Frontiers in Pharmacology
The Sec61 complex, which is located on the membrane of the mammalian endoplasmic reticulum (ER), serves as a pivotal component of protein transport channels.
Jingxin Xin, Jingxin Xin, Jingxin Xin, Jingxin Xin, Jingxin Xin, Keling Yin, Keling Yin, Keling Yin, Keling Yin, Keling Yin, Shimeng Li, Shimeng Li, Shimeng Li, Shimeng Li, Shimeng Li, Peiyuan Gu, Peiyuan Gu, Peiyuan Gu, Peiyuan Gu, Peiyuan Gu, Shanshan Shao, Shanshan Shao, Shanshan Shao, Shanshan Shao, Shanshan Shao, Shanshan Shao   +25 more
doaj   +2 more sources

Dissecting structures and functions of SecA-only protein-conducting channels: ATPase, pore structure, ion channel activity, protein translocation, and interaction with SecYEG/SecDF•YajC. [PDF]

PLoS ONE, 2017
SecA is an essential protein in the major bacterial Sec-dependent translocation pathways. E. coli SecA has 901 aminoacyl residues which form multi-functional domains that interact with various ligands to impart function. In this study, we constructed and
Ying-Hsin Hsieh, Ying-Ju Huang, Hao Zhang, Qian Liu, Yang Lu, Hsiuchin Yang, John Houghton, Chun Jiang, Sen-Fang Sui, Phang C Tai   +9 more
doaj   +1 more source

Structure of the posttranslational Sec protein-translocation channel complex from yeast [PDF]

Science, 2019
Posttranslational translocon architecture About a third of proteins are transported into endoplasmic reticulum by the universally conserved Sec61 protein-conducting channel. Itskanov and Park determined a cryo–electron microscopy structure of the Sec complex from yeast, which mediates posttranslational translocation of many secretory ...
Samuel Itskanov, Eunyong Park
openaire   +5 more sources

Through the Eye of the Needle: Recent Advances in Understanding Biopolymer Translocation [PDF]

, 2013
In recent years polymer translocation, i.e., transport of polymeric molecules through nanometer-sized pores and channels embedded in membranes, has witnessed strong advances.
Barkema, Gerard T., Kolomeisky, Anatoly B., Panja, Debabrata   +2 more
core   +6 more sources

Structure of the SecY Complex Unlocked by a Preprotein Mimic

Cell Reports, 2012
The Sec complex forms the core of a conserved machinery coordinating the passage of proteins across or into biological membranes. The bacterial complex SecYEG interacts with the ATPase SecA or translating ribosomes to translocate secretory and membrane ...
Dilem Hizlan, Alice Robson, Sarah Whitehouse, Vicki A. Gold, Janet Vonck, Deryck Mills, Werner Kühlbrandt, Ian Collinson   +7 more
doaj   +1 more source

Controlling Polymer Capture and Translocation by Electrostatic Polymer-Pore Interactions [PDF]

, 2017
Polymer translocation experiments typically involve anionic polyelectrolytes such as DNA molecules driven through negatively charged nanopores. Quantitative modelling of polymer capture to the nanopore followed by translocation therefore necessitates the
Abramowitz M., Risken H., Rowghanian P., Sahin Buyukdagli, T. Ala-Nissila   +4 more
core   +2 more sources

Extragenic Suppression analysis of TS mutations using Sec61p [PDF]

, 2007
During synthesis, secretory and membrane proteins are cotranslationally translocated into the lumen of the endoplasmic reticulum through an aqueous gated channel.
Sterling Smith
core   +2 more sources

Abnormal Action Potentials Associated with the Shaker Complex Locus of Drosophila [PDF]

, 1981
Intracellular recordings of action potentials were made from the cervical giant axon in Shaker (Sh) mutants and normal Drosophila. The mutants showed abnormally long delays in repolarization.
Ferrus, Alberto, Fujita, Shinobu C., Tanouye, Mark A.   +2 more
core   +1 more source

Endothelial preconditioning by transient oxidative stress reduces inflammatory responses of cultured endothelial cells to TNF-α [PDF]

, 2000
Brief episodes of ischemia can render an organ resistant to subsequent severe ischemia. This ‘ischemic preconditioning’ is ascribed to various mechanisms, including oxidative stress. We investigated whether preconditioning exists on an endothelial level.
Akimitsu T., BERNHARD F. BECKER, CHRISTIAN KUPATT, DeFily D. V., Hearse D. J., Hoshida S., Jerome S. N., Schreck R., Schulz R., Siegfried M. R., STEFAN ZAHLER, Yao Z.   +11 more
core   +1 more source

Conformational Dynamics of the Plug Domain of the SecYEG Protein-conducting Channel [PDF]

, 2011
The central pore of the SecYEG preprotein-conducting channel is closed at the periplasmic face of the membrane by a plug domain. To study its conformational dynamics, the plug was labeled site-specifically with an environment-sensitive fluorophore.
Arkowitz, Baneyx, Becker, Bol, Bonardi, Bondar, Cabelli, De Keyzer, Driessen, du Plessis, Duong, Egea, Evans, Fekkes, Frauenfeld, Greenough, Gumbart, Hanahan, Harris, Joly, Junne, Klose, Kusters, Lakowicz, Li, Lin, Lycklama, Maillard, Manting, Ménétret, Nakatogawa, Osborne, Plath, Prinz, Ramachandran, Rutkowska, Schaffitzel, Smith, Tam, Tsukazaki, Van den Berg, van der Does, van der Sluis, Zhang, Zimmer   +44 more
core   +2 more sources