Advanced Science, EarlyView.Lipid overload suppresses SREBF2‐mediated FNTB expression, leading to defective Lamin A maturation and nuclear envelope instability. This nuclear catastrophe triggers a pro‐fibrotic senescence program in cardiomyocytes. Notably, restoring nuclear integrity via AAV9‐based gene therapy effectively attenuates cardiac remodeling, identifying the ...
Yuxiao Chen +16 more
wiley +1 more source
Study on the mechanical behavior and fracturing mechanism of rock containing two unparallel prefabricated fissures under uniaxial loading. [PDF]
PLoS OneLi J, Wei Y, Wang T.
europepmc +1 more source
Endocytic Control of Cell‐Autonomous and Non‐Cell‐Autonomous Functions of p53
Advanced Science, EarlyView.NUMB Ex3‐containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells and activates nuclear programs, revealing an intercellular, exosome‐based pathway that might help establish a tumor‐suppressive microenvironment.
Roberta Cacciatore +20 more
wiley +1 more source
Numerical simulation of mechanical properties of a new type of assembly shear wall horizontal connection device. [PDF]
Sci RepTian P +5 more
europepmc +1 more source
The Uppsala APP Mutation Promotes Wild‐Type Amyloid‐β Aggregation and Deposition In Vivo
Advanced Science, EarlyView.We investigated in vivo cross‐seeding of amyloid‐β (Aβ) isoforms in transgenic mice co‐expressing wild‐typeAβ and the Uppsala‐mutant Aβ variant (AβUpp), lacking six central residues. Weleveraged MALDI‐MS imaging and hyperspectral microscopy to follow spatio‐temporalAβ deposition.
Junyue Ge +14 more
wiley +1 more source
Hydrogen Solubility in Metal Membranes: Critical Review and Re-Elaboration of Literature Data. [PDF]
Membranes (Basel)Prenesti G +5 more
europepmc +1 more source
A note on inexact secant methods
Journal of Numerical Analysis and Approximation Theory, 1996 The inexact Newton method \[ F'(x_k) (x_{k+1} -x_k)= -F(x_k) +r_k \] for the approximate solution of the equation \(F(x)=0\), \(F:\mathbb{R}^n \to\mathbb{R}^n\) is studied \((r_k\) is an error term). Necessary and sufficient conditions on the magnitude of \(r_k\) are imposed for certain convergence order to be achieved.
openaire +3 more sources
Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs
Advanced Science, EarlyView.Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou +22 more
wiley +1 more source
Stress and stiffness analysis of the multiple corrugated diaphragm under angular load based on plate and shell theory. [PDF]
Sci RepCao A, Jin H, Li W, Jiang S.
europepmc +1 more source
Improved Systemic Immunochemotherapy Employing an Oxaliplatin‐TLR7/8 Agonist Prodrug Strategy
Advanced Science, EarlyView.A platinum(IV) prodrug is developed to systemically deliver the TLR7/8 agonist gardiquimod. Tumor‐targeting is mediated by an albumin‐binding maleimide, which limits premature complex activation. Ox‐Gardi‐Mal accumulates specifically in the tumor, where it activates the immune system.
Michael Gutmann +15 more
wiley +1 more source