Results 41 to 50 of about 438,741 (228)

Modeling high-frequency financial data using R and Stan: A bayesian autoregressive conditional duration approach

Journal of Open Innovation: Technology, Market and Complexity
In econometrics, Autoregressive Conditional Duration (ACD) models use high-frequency economic or financial duration data, which mostly exhibit irregular time intervals.
Mosab I. Tabash, T. Muhammed Navas, P.V. Thayyib, Shazia Farhin, Athar Ali Khan, Azzam Hannoon   +5 more
doaj   +1 more source

Synthesizing Imperative Programs from Examples Guided by Static Analysis

, 2017
We present a novel algorithm that synthesizes imperative programs for introductory programming courses. Given a set of input-output examples and a partial program, our algorithm generates a complete program that is consistent with every example.
A Albarghouthi, A Ireland, AV Aho, G Katz, MA Colón, R Singh, T Gvero   +6 more
core   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Phobos: A front-end approach to extensible compilers (long version) [PDF]

, 2002
This paper describes a practical approach for implementing certain types of domain-specific languages with extensible compilers. Given a compiler with one or more front-end languages, we introduce the idea of a "generic" front-end that allows the ...
Granicz, Adam, Hickey, Jason
core   +2 more sources

Towards a Tool-based Development Methodology for Pervasive Computing Applications [PDF]

, 2012
Despite much progress, developing a pervasive computing application remains a challenge because of a lack of conceptual frameworks and supporting tools. This challenge involves coping with heterogeneous devices, overcoming the intricacies of distributed ...
Balland, Emilie, Bruneau, Julien, Cassou, Damien, Consel, Charles   +3 more
core   +5 more sources

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

PyCUDA and PyOpenCL: A Scripting-Based Approach to GPU Run-Time Code Generation

, 2011
High-performance computing has recently seen a surge of interest in heterogeneous systems, with an emphasis on modern Graphics Processing Units (GPUs).
Ahmed Fasih, Andreas Klöckner, Bell, Bryan Catanzaro, Buck, Chandler, Dalcín, Eich, Feldman, Flanagan, Frigo, Group, Hestenes, Hesthaven, Kennedy, Klöckner, Lam, Langtangen, Lindholm, McCarthy, McCool, Nicolas Pinto, Oliphant, Owens, Paul Ivanov, Pinto, Pinto, Prud’homme, Reynders, Seiler, Stein, Valiant, van Hateren, Veldhuizen, Wang, Whaley, Yunsup Lee   +36 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Metamodel Instance Generation: A systematic literature review [PDF]

, 2012
Modelling and thus metamodelling have become increasingly important in Software Engineering through the use of Model Driven Engineering. In this paper we present a systematic literature review of instance generation techniques for metamodels, i.e.
Monahan, Rosemary, Power, James F., Wu, Hao   +2 more
core   +3 more sources