Results 141 to 150 of about 4,270,653 (326)
The TR-BDF2 method for second order problems in structural mechanics [PDF]
, 2020 Luca Bonaventura +1 more
openalex +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Nonreciprocal photon blockade in a two-mode cavity with a second-order nonlinearity [PDF]
, 2019 Kai Wang +3 more
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Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Second-order sound field during megasonic cleaning of patterned silicon wafers: Application to ridges and trenches [PDF]
, 2001 P. A. Deymier +3 more
openalex +1 more source
Publicacions Matemàtiques, 1992 The author introduces the notion of a \(G_ 1\)-structure of order 2 (briefly \(G^ 2_ 1\)- structures.) Let us recall that a \(G_ 1\)- structure on a manifold \(V\) is defined by an endomorphism \(J\) of the tangent bundle \(TV\) with constant rank and such that \(J^ 2 = 0\). Then a \(G^ 2_ 1\)-structure is a generalization of almost tangent structures.
openaire +7 more sources
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
On the Cauchy problem for hyperbolic operators of second order whose coefficients depend only on the time variable [PDF]
, 2010 Seiichiro Wakabayashi
openalex +1 more source