Results 191 to 200 of about 3,317,233 (282)

The enchanted loom of artificial general intelligence. [PDF]

Natl Sci Rev
Poo MM.
europepmc   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Microsurgical resection of anterior clinoidal meningiomas with arterial engulfment: lessons from 2 contrasting cases. [PDF]

Neurosurg Focus Video
Sulaimanov U, Erginoglu U, Keles A, Serikkanov Y, Vera Figueroa F, Sevgi UT, Ozturk O, Baskaya MK.   +7 more
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Using Participatory Methods to Create Informational Videos for Inclusive Brain Stimulation Research Recruitment: Action Research Study and Pilot Randomized Controlled Trial. [PDF]

J Particip Med
Wong ML, McTeague LM, Miller CA, Gonzalez G, Tovin MM, Penedo FJ, Widerstrom-Noga E.   +6 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

The post-pandemic pivot: mRNA therapeutics enter the chronic rare disease arena. [PDF]

Mol Ther Nucleic Acids
Giangrande PH.
europepmc   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Disclosure experiences in LGBTQ+ healthcare staff: a systematic review and meta-synthesis. [PDF]

BMJ Open
Prakkash R, Manning L, Bécares L, Hatch SL, Akande I, Dorrington S.   +5 more
europepmc   +1 more source