Results 41 to 50 of about 359,102 (251)
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
What Went Wrong? Rethinking the Sandinista Revolution, in Light of Its Second Coming
Latin American Research Review, 2017 This essay reviews the following works: Faith and Joy: Memoirs of a Revolutionary Priest. By Fernando Cardenal, S. J. Translated and edited by Kathy McBride and Mark Lester. Maryknoll, NY: Orbis Books, 2015. Pp. xxvi + 288. $28.00 paper.
Charles R. Hale
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
TheoRhēma, 2015 The paper deals with the issue relating to the imminence of the Parousia based on 2 Timothy 3:1–5. It answers two questions. The first is how sure are the signs that are behavioural in nature to indicate the nearness of Jesus’ second coming?
Laurențiu Moț
doaj
Estimation of Effect of Foreign Direct Investment on the Russian Economy during Sanctions Based on Spillover Effects [PDF]
Пространственная экономика, 2018 The study estimates the effect of foreign direct investments (FDI) on the efficiency of enterprises in Russia. The article test the following hypotheses: first – FDI coming from the countries that sanctioned Russia cause larger effect on the efficiency ...
Elena Anatolievna Fedorova +3 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
In die Skriflig, 2008 Pentecostals regard the doctrine of the second coming of Christ as very important. All passages in the Bible deemed to be “prophetical” are interpreted in premillennialist terms.
M. Nel
doaj +1 more source