Results 81 to 90 of about 970,596 (298)

Real‐World Investigation of Satralizumab in Patients With Neuromyelitis Optica Spectrum Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Satralizumab, a monoclonal antibody targeting the interleukin‐6 receptor, has demonstrated efficacy in clinical trials for neuromyelitis optica spectrum disorder (NMOSD). However, its real‐world effectiveness and safety compared to conventional immunosuppressive therapies remain uncertain.
Li‐Tsung Lin   +2 more
wiley   +1 more source

Fibrinogen Changes Before and After Intravenous Thrombolysis as Predictors of Cerebral Injury and Clinical Outcomes in Acute Ischemic Stroke: A Multicenter Prospective Cohort Study

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Plasma fibrinogen is essential in thrombosis and fibrinolysis, yet its dynamic changes pre‐ and post‐intravenous thrombolysis (IVT) for predicting brain injury severity and prognosis in acute ischemic stroke (AIS) patients remain unclear.
Wenhai Zhai   +28 more
wiley   +1 more source

Overview Chapter 6: The diverse faces of the Second Demographic Transition in Europe [PDF]

open access: yes
This chapter discusses the concept of the second demographic transition (SDT) and its relevance for explaining the ongoing changes in family and fertility patterns across Europe.
Tomas Sobotka
core  

Fertility and regional development in Portugal: from the first to the second demographic transition [PDF]

open access: yes, 2015
Portuguese regions are quite different regarding several development indicators, such as educational levels, regional value added per capital, purchasing power, and others.
Nogueira, Joana
core  

Changes in Immune‐Inflammation Status and Acute Ischemic Stroke Prognosis in Prospective Cohort

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Inflammation is a critical risk factor for poor outcomes in cerebral infarction. Prior studies focused primarily on baseline inflammation status, neglecting dynamic longitudinal changes. We try to investigate the association between immune‐inflammation status alterations and stroke prognosis, and evaluated three systemic biomarkers'
Songfang Chen   +11 more
wiley   +1 more source

Depopulation and deep aging: the former Yugoslav and Western Balkans space between the second demographic transition and emigration

open access: yesStanovništvo
The article introduces the tentative concept of deep aging – a label used for a situation when the overall ageing effects of the second demographic transition, due to fertility below replacement level, are topped by the excessive emigration of the ...
Damir Josipovič
doaj   +1 more source

The impact of union formation dynamics on first births in West Germany and Italy: are there signs of convergence? [PDF]

open access: yes
In this paper we investigate the changing impact of union formation on the transition to parenthood in West Germany and Italy using FFS data. We first draw attention to overall cohort patterns in union formation and first births and then describe the ...
Francesco C. Billari, Hans-Peter Kohler
core  

Exploratory Analysis of ELP1 Expression in Whole Blood From Patients With Familial Dysautonomia

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Familial dysautonomia (FD) is a hereditary neurodevelopmental disorder caused by aberrant splicing of the ELP1 gene, leading to a tissue‐specific reduction in ELP1 protein expression. Preclinical models indicate that increasing ELP1 levels can mitigate disease manifestations.
Alejandra González‐Duarte   +13 more
wiley   +1 more source

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