Results 101 to 110 of about 421,004 (299)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Measuring the impact of Educational Interventions on the Academic Performance of Academic Development Students in Second-Year Microeconomics [PDF]

This paper analyses the impact of educational interventions made in the first- and second-year microeconomics courses on academic development students’ final mark in the second-year course.
Leonard Smith, Vimal Ranchhod
core   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

The impact of sociocultural theory-informed instruction on learners’ IELTS writing: task response, grammar, vocabulary, coherence and cohesion

Asian-Pacific Journal of Second and Foreign Language Education
This study explores the impact of sociocultural theory-based instruction on enhancing L2 learners’ writing skills including grammatical accuracy, coherence, cohesion, task response, and lexical resources for the IELTS.
Hamid Allami, Boshra Najari, Zia Tajeddin   +2 more
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Persian Learners' Acquisition of Empty Categories in English Null Operator Structures [PDF]

Teaching English Language, 2019
The study investigated the acquisition of empty categories in the English complex infinitival structures. A quasi-experimental design was used in which four groups of Persian learners of English (elementary, lower intermediate, upper intermediate and ...
Vahid Mahmoudi-Gahroue, Manijeh Youhanaee, Dariush Nejadansari   +2 more
doaj  

Reconsidering the Backward Vertical Linkages of Foreign Affiliates: Evidence from Japanese Multinationals [PDF]

This paper examines the determinants of the backward vertical linkages of Japanese foreign affiliates in manufacturing for the period 1994-2000, focusing on the local backward linkages, or local procurements in the host country.
Toshiyuki Matsuura, Kozo Kiyota, Shujiro Urata, Yuhong Wei   +3 more
core  

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

One interesting and elusive two-coupled oscillator problem

Neurobiology of Sleep and Circadian Rhythms
Chronobiology experiments often reveal intriguing non-linear phenomena, which require mathematical models and computer simulations for their interpretation. One example is shown here, where the two circadian oscillators located in the eyes of the mollusk
Gisele A. Oda
doaj   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source