Results 181 to 190 of about 925,120 (310)

Transfusion-Related Iron Overload in Children With Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma: Addressing an Overlooked Treatment Complication. [PDF]

Cureus
Matijasic Stjepovic N, Kranjcec I, Resic A, Sila S, Cavar A, Ruzman L, Trbusic E, Stepan Giljevic J.   +7 more
europepmc   +1 more source

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

Iron concentration in the ventral pallidum of chronic migraine with medication-overuse headache. [PDF]

J Headache Pain
Xu X, He J, Zhou M, Wu X, Zhao F, Fu J, Luo X, Li K, Zeng Q, Wang C, Guan X, Huang P, Zhang M, Liu K.   +13 more
europepmc   +1 more source

Contribution to the knowledge of the temperatures reached during the cremation rites in the roman peoples of the second iron age in the iberian peninsula [PDF]

International Journal of Recent Scientific Research, 2017
García Sánchez L, Criado Martín A. J, Penco Valenzuela F, Criado Portal A. J, Gómez De Salazar Y Caso De Los Cobos J.M, Will Queirós G   +5 more
openaire   +1 more source

Climate Change Threatens Micronutrient Density of European Winter Wheat

Advanced Science, EarlyView.
Micronutrients are vital for human health. Wheat is a major staple crop and a significant source of minerals and B‐vitamins. The impact of climate change on their content remains largely unknown. We evaluated micronutrient levels in European winter wheat grown under historical and projected climate conditions. Our findings indicate that future climates
Da Cao, Jennifer Michel, Eline Lorer, Markus Weinmann, Jacques Le Gouis, Claire Léon, Sibille Perrochon, David Alvarez, Vincent Leemans, Iñaki Balanzategui Guijarro, Jordi Moya Laraño, Sara Sánchez Moreno, Symanczik Sarah, Waibel Matthias, Hervé Vanderschuren, Cécile Thonar, Pierre Delaplace, Dominique Van Der Straeten   +17 more
wiley   +1 more source

Causal relationship between autoimmune diseases and iron deficiency anemia: a two-sample mendelian randomization study. [PDF]

Sci Rep
Chen W, Wang Y, Long H, Yang Y, Liu Y, Xiao J, Lu Q, Shu Y, Liang D, Zhai L.   +9 more
europepmc   +1 more source

Material‐Induced Nuclear Deformation Controls Chromatin Architecture in Adipose Stem Cells

Advanced Science, EarlyView.
Tuning cell and cytoskeleton mechanics modulated nuclear shape and heterochromatin organization in ASCs. Distinct cytoskeletal architectures induced nuclear morphologies from oblate to prolate ellipsoids. Large elongated cells with a structured actin cap exhibited high nuclear strain, driving nuclear envelope deformation and heterochromatin ...
Carlo F. Natale, Luca Messina, Valeria Panzetta, Stefania Saporito, Costantino Menna, Maurizio Ventre, Paolo A. Netti   +6 more
wiley   +1 more source

Ancient DNA reveals 4000 years of grapevine diversity, viticulture and clonal propagation in France. [PDF]

Nat Commun
Noraz R, Chauvey L, Wagner S, Estrada O, Wales N, Bonnaire E, Cabanis M, Derreumaux M, Figueiral I, Hallavant C, Marinval P, Matterne V, Ros J, Rovira N, Tillier M, Bovagne M, Chausserie-Laprée J, Nicolas C, Daveau I, Delassus D, Gailledrat E, Ginouvez O, Houix B, Jung C, Kuchler P, Leroux L, Macario R, Marlière E, Pasqualini M, Piques G, Pomaredes H, Robert J, Roms C, Roth-Zehner M, Scrinzi M, Taras-Thomas M, Torres Costa J, Besnard G, Terral JF, Bacilieri R, Bouby L, Orlando L.   +41 more
europepmc   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Targeting Peptostreptococcus anaerobius with an Iron‐Based Nanozyme Reverses Ferroptosis Resistance and Enhances Antitumor Immunity in Colorectal Cancer

Advanced Science, EarlyView.
An iron‐based nanozyme selectively eliminates intratumoral P. anaerobius while catalytically generating ROS to induce ferroptosis, synergistically suppressing colorectal cancer growth and activating anti‐tumor immunity through immunogenic cell death. ABSTRACT The intratumoral microbiota is a critical determinant of therapeutic outcomes in colorectal ...
Yinghao Cao, Jun Wang, Hanwenchen Wang, Xiang Sun, Fang Fang, Shiying Li, Jianping Liu, Changrong Shi, Pengyuan Qi, Jianhua Zou, Xiaoyuan Chen, Kailin Cai   +11 more
wiley   +1 more source