Results 141 to 150 of about 16,052,874 (333)
A Different Kind of Property Cluster Kind [PDF]
, 2011 Richard Boyd (1988, 1991, 1999) has long campaigned for a view of natural kinds he calls the Homeostatic Property Cluster (HPC) account. This account has been particularly exciting for philosophers of biology unhappy with traditional essentialism about ...
Slater, Matthew
core
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
A Remark on the Interaction of the Second Kind [PDF]
Progress of Theoretical Physics, 1955 openaire +1 more source
Set mainly in the small towns of Alabama, the stories in Her Kind of Want ache with the relentless longing of the poor, struggling, usually discarded southern women who tell us their lives--lives that seem to revolve around men whose only presence is ...
Davis, Jennifer S.
core
Pareto improvements by in-kind-transfers [PDF]
This paper shows that in-kind-transfers are an effective instrument to stabilize agreements when compliance cannot be guaranteed. It demonstrates the weak superiority of in-kind-transfers for a unilateral relationship between two agents.
Stähler, Frank
core
Motivation and willingness to communicate as predictors of reported L2 use: The Japanese ESL context [PDF]
, 2002 The purpose of this study was to examine affective variables as predictors of reported second language (L2) use in classrooms of Japanese ESL (English as a Second Language) students.
Hashimoto, Yuki
core
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source