Results 111 to 120 of about 825,806 (292)

Pattern of second primary malignancies in thyroid cancer patients

, 2013
Many factors, including relatively young age of thyroid cancer diagnoses and improved survival, have led to increased concerns about the occurrence of second primary malignancies.
Shamim, SA, Shandra, V, Sellam, K, Olusina, DB, Bal, C, Okere, PCN, Tushar, M   +6 more
core   +1 more source

Analysis of the structure of deaths from sporadic metachronous primary multiple malignant neoplasms in a general hospital

Бюллетень сибирской медицины
Aim. To analyze the structure of deaths from sporadic metachronous primary multiple malignant neoplasms in 2017–2023 in a multidisciplinary inpatient facility.Materials and methods.
M. V. Zavyalova, A. V. Zavyalov, D. S. Pismenny, L. V. Pikalova, L. D. Zhuykova, Yu. M. Zhuykova, M. Yu. Grishchenko, S. V. Vtorushin, N. V. Litvyakov, M. V. Perelmuter   +9 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Secondary primary tumor mimicking osteoradionecrosis

Autopsy and Case Reports, 2022
Nasopharyngeal carcinoma (NPC) is a malignant tumor rarely found in the head and neck, representing about 1% of all malignancies. The main treatment for NPC is radiation therapy, which is often given in combination with chemotherapy.
Giovanna Lopes Carvalho, Daniele Heguedusch, Antônio Cássio Assis Pellizzon, Renan Bezerra Lira, Fábio Abreu Alves, Graziella Chagas Jaguar   +5 more
doaj  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Second primary cancers in the Vaud and Neuchâtel cancer Registries

, 2015
An increasing proportion of new cancers is registered in patients who have received a previous cancer diagnosis. As data are inconsistent across studies, we provided information for populations long covered by valid cancer registration. Data were derived
B. Rafael, M. Manuela, C. La Vecchia, L. Randimbison, F. Levi   +4 more
core   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Occurrence of second primary malignancies in patients with neuroendocrine tumors of the digestive tract: A case report

, 2019
There is an association between the presence of neuroendocrine neoplasms and incremented risk to develop second primary malignancies. This risk is estimated to be 17%.
Cartenì, Giacomo, Arpino, Grazia, Campione, Severo, Molino, Carlo, Pirozzi, Angelo, Riccardi, Ferdinando, Mocerino, Carmela   +6 more
core   +1 more source

Secondary gliosarcoma transformed from lower grade glioma: one case report

Chinese Journal of Contemporary Neurology and Neurosurgery, 2019
Objective A case of secondary gliosarcoma transformed from lower grade glioma was analyzed. The clinicopathological features, molecular pathological features and prognosis of secondary gliosarcoma were discussed with relevant literatures.
Wei GUO, Jing⁃hui LIU, Pei⁃gang JI, Miao LOU, Yu⁃long ZHAI, Guo⁃dong GAO, Yan QU, Liang WANG   +7 more
doaj  

[Second primary neoplasms in laryngeal cancer patients].

Otolaryngologia polska = The Polish otolaryngology, 1999
In the period of 1990-1992, 238 patients underwent surgical treatment for laryngeal carcinoma in ORL Department of Medical Academy in Białystok. Until now 27 cases of second primary malignances (SPM) have been found in this group (11.3% of the screened population). Upper aerodigestive tract was the most frequent location, i.e.
K, Szafałowicz, E, Hassmann-Poznańska, B, Musiatowicz   +2 more
openaire   +1 more source