Results 111 to 120 of about 2,096,986 (304)
, 2012 On 2 July 1942, two young Canadian soldiers on duty drowned in the Rideau Canal in downtown Ottawa.
Purchase, Gerry
core +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
A Tariff-Growth Paradox? Protection's Impact the World Around 1875-1997 [PDF]
This paper uses a new database to establish two findings covering the first globalization boom before World War I, the second since World War II, and the autarkic interlude in between.
Jeffrey G. Williamson +1 more
core
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Estimates of mortality and population changes in England and Wales over the two World Wars
Demographic Research, 2005 Almost one million soldiers from England and Wales died during the First and Second World War whilst serving in the British Armed Forces. Although many articles and books have been published that commemorate the military efforts of the British Armed ...
Evgueni Andreev +3 more
doaj
Soldiers’ Lives Depicted: Paintings and Drawings by “Unofficial Artists” in the Collection of the Canadian War Museum [PDF]
, 2012 The Canadian War Museum’s collection of Second World War art, collectively entitled “The Canadian War Records,” is primarily made up of artwork officially commissioned by the National Gallery of Canada on behalf of the Canadian Government.
Marcus, Angela
core +1 more source