Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
The development of albumin solutions in the Second World War. [PDF]
Anaesth Intensive Care, 2023 Featherstone PJ, Ball CM.
europepmc +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
After Arizona: Military Musicians in the Second World War
Revue LISA, 2012 Cet article traite du rôle des musiciens dans la marine américaine pendant la Seconde Guerre mondiale. L’histoire de l’USS Arizona — et de son orchestre, noyé avec le cuirassé lors de l’attaque surprise des forces japonaises — étant bien connue, je m ...
Rosemary Peters
doaj +1 more source
From conflict to controversy: the use and abuse of human albumin solutions after the Second World War. [PDF]
Anaesth Intensive Care, 2023 Featherstone PJ, Ball CM.
europepmc +1 more source
“The Necessary War: Canadians Fighting the Second World War 1939–1943, Volume One (Book Review)” by Tim Cook & “Fight to the Finish: Canadians in the Second World War 1944–1945, Volume Two (Book Review)” by Tim Cook [PDF]
, 2017 Review of The Necessary War: Canadians Fighting the Second World War 1939–1943, Volume One & Fight to the Finish: Canadians in the Second World War 1944–1945, Volume Two by Tim ...
Wiseman, Matthew S.
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Plasmodium vivax Relapse Rates in Allied Soldiers during the Second World War: Importance of Hypnozoite Burden. [PDF]
Am J Trop Med Hyg, 2022 Shanks GD.
europepmc +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Crossing the Canal: Combined Arms Operations at the Canal Du Nord, Sept–Oct 1918 [PDF]
, 2012 The crossing of the Canal du Nord stands as one of the most impressive Canadian tactical operations of the First World War. Incorporating a risky battle plan, emphasizing combined arms operations and utilizing the recently re-organized Canadian Engineers,
Borys, David
core +1 more source