Results 51 to 60 of about 6,193,188 (319)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

The Impact of Economic Literacy Components on Entrepreneurship Potential Among Secondary School Students in Sik, Kedah

Educational Process: International Journal
Background/purpose. Entrepreneurs are the catalyst of change, innovation, and growth in any country. The contribution of entrepreneurship activities to the growth and prosperity of any nation is undeniably affirmed. Nurturing entrepreneurship potential
Bakare Kazeem Kayode, Kalthom Husain, Osaid N A Abdaljawwad   +2 more
doaj   +1 more source

Primary and Secondary Variants of Callous-Unemotional Traits in Community Youths: Differences in Anticipatory Fear

Children
Callous-unemotional (CU) traits refer to a cluster of characteristics such as low empathy, lack of remorse, and insensitivity to the emotions of others, delineating a group of youth at high risk for severe antisocial behavior.
Yu Gao, Adrian Raine
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Differentiating Primary and Secondary Hypothermia in a Rat Model: The Role of Biochemical Markers in Postmortem Analysis

Applied Sciences
Postmortem biochemistry is a valuable tool in forensic investigations, providing insights into the tissue damage and organ dysfunction associated with death.
Emina Dervišević, Džan Ahmed Jesenković, Aida Bešić, Nedim Šuta, Aida Selmanagić, Zurifa Ajanović, Edina Lazović, Muhamed Katica, Adis Salihbegović   +8 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Geographical terms in English and Burmese arranged in alphabetical order : report of the Sub-Committee appointed by the Secondary Schools Board, at its meeeting held on the 25th June 1934.

, 1935
Electronic reproduction. Canberra, A.C.T.
Burma. Secondary School Board.
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source