Results 101 to 110 of about 1,145,423 (310)

An alternative technical education system : a case study of Mexico [PDF]

open access: yes
Many developing countries have relied on the varied forms of diversified secondary technical education as the main venue for training skilled workers and mid-level technicians.
Kye Woo Lee
core  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Social Support and Social Adjustment Among Chinese Secondary School Students: The Mediating Roles of Subjective Well-Being and Psychological Resilience

open access: yesPsychology Research and Behavior Management
Lanqi Yu,1,2 Xiaolu Wu,1,2 Qinhan Zhang,1,2 Binghai Sun1,2 1School of Psychology, Zhejiang Normal University, Jinhua, Zhejiang, People’s Republic of China; 2Intelligent Laboratory of Child and Adolescent Mental Health and Crisis Intervention of Zhejiang ...
Yu L, Wu X, Zhang Q, Sun B
doaj  

HTX-011 reduced pain intensity and opioid consumption versus bupivacaine HCl in bunionectomy: phase III results from the randomized EPOCH 1 study. [PDF]

open access: yes, 2019
BACKGROUND AND OBJECTIVES: There is a need for local anesthetics that provide consistent analgesia through 72 hours after surgery. This study evaluates the use of HTX-011 (bupivacaine and meloxicam in Biochronomerpolymer technology), an extended-release,
Gimbel, Joseph S.   +4 more
core   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

The efficacy of life skills training on marital adjustment of women for the prevention of domestic violence [PDF]

open access: yesروانشناسی و روانپزشکی شناخت, 2016
Purpose: This study examined the impact of life skills training on marital adjustment of women for the prevention of domestic violence. Method: This was a semi-experimental study with pre-test and post-test design.
Mahdi Naeim, Ali Rezaei Sharif
doaj  

A Summary of Large Capacity Power Energy Storage Peak Regulation and Frequency Adjustment Performance

open access: yes发电技术, 2018
It will lead to the problem of frequency adjustment when the large-scale new energy integrated in the power grid, and large capacity power energy storage is one of the effective solutions for the problem.
Xiankui WEN   +4 more
doaj   +1 more source

Trees adjust nutrient acquisition strategies across tropical forest secondary succession

open access: yesNew Phytologist
Summary Nutrient limitation may constrain the ability of recovering and mature tropical forests to serve as a carbon sink. However, it is unclear to what extent trees can utilize nutrient acquisition strategies – especially root phosphatase enzymes and mycorrhizal symbioses – to overcome low nutrient availability across secondary succession. Using a
Michelle Y. Wong   +8 more
openaire   +3 more sources

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira   +14 more
wiley   +1 more source

Home - About - Disclaimer - Privacy