Results 231 to 240 of about 1,162,640 (307)

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Efficacy and Safety of PHPV Fusion Factor Vaginal Gel (PHPV®) in Clearing Cervical Persistent High-Risk Human Papillomavirus Infection: A Randomized Controlled Clinical Trial. [PDF]

Drug Des Devel Ther
Yan L, Yin H, Shi L, Ding B, Liu C, Wang Y, Fu C.   +6 more
europepmc   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Effectiveness of a family-school-community collaborative physical activity intervention. [PDF]

Front Public Health
Kong L, Chen X, Gong B, Zhang X, Guo M.
europepmc   +1 more source

Poor adjustment to nursing homes and 1-year mortality: a secondary analysis of the KASEHPAD cohort study. [PDF]

BMJ Open
Boucaud-Maitre D, Amieva H, Pic O, Letchimy L, Simo N, Dartigues JF, Dramé M, Dorey JM, Tabué-Teguo M.   +8 more
europepmc   +1 more source

Association of smoking with serum uric acid levels, hyperuricemia, and gout based on the 7th to 9th Korea National Health and Nutrition Examination Survey: A secondary dataset analysis based on a cross-sectional study. [PDF]

Tob Induc Dis
Kim S.
europepmc   +1 more source