Results 71 to 80 of about 1,162,640 (307)

Efficacy and Safety Analysis of Roxarestat in Regulating Renal Anemia in Patients on Maintenance Hemodialysis

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Objective To compare the efficacy and safety of roxarestat versus recombinant human erythropoietin (rhEPO) in the management of renal anemia in patients undergoing maintenance hemodialysis. Methods This was a prospective, open‐label, randomized controlled trial.
Lingling Chen, Junjie Zhu, Qiaonan Ge
wiley   +1 more source

The Effect of the Fear of COVID-19 on Healthcare Professionals’ Psychological Adjustment Skills: Mediating Role of Experiential Avoidance and Psychological Resilience

open access: yesFrontiers in Psychology, 2020
As the COVID-19 outbreak is rapidly spreading all over the world, it’s secondary consequences will negatively affect both societies and individuals. The target group, expected to be exposed to the secondary negative consequences most intensely during the
İsmail Seçer   +2 more
doaj   +1 more source

Adjusting for observational secondary treatments in estimating the effects of randomized treatments [PDF]

open access: yesBiostatistics, 2013
In randomized clinical trials, for example, on cancer patients, it is not uncommon that patients may voluntarily initiate a secondary treatment postrandomization, which needs to be properly adjusted for in estimating the "true" effects of randomized treatments.
Min, Zhang, Yanping, Wang
openaire   +2 more sources

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

MARKET ADJUSTMENT INSIGHTS: PRIMARY VS. SECONDARY DATA [PDF]

open access: yes
Producers, researchers, and policy makers have an interest in market effects from meatpacking plant closings and openings. This paper presents results from a study taking a dual approach to determining impacts from an anticipated hog slaughtering plant ...
Hornung, Jonathan T., Ward, Clement E.
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Predictive value of prior academic and psychosocial factors on first-year students’ academic achievement at Wallaga University

open access: yesCogent Education
This study aims to determine to what extent prior academic performance (secondary school Grade Point Average (GPA) and Ethiopian University Entrance Exam (EUEE) scores) and the psychosocial factors (academic motivation, self-esteem, academic self ...
Adugna Bersissa Merdassa
doaj   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

The G-protein Coupled Receptor GPR8 Regulates Secondary Metabolism in Trichoderma reesei

open access: yesFrontiers in Bioengineering and Biotechnology, 2020
Changing environmental conditions are of utmost importance for regulation of secondary metabolism in fungi. Different environmental cues including the carbon source, light and the presence of a mating partner can lead to altered production of compounds ...
Wolfgang Hinterdobler   +5 more
doaj   +1 more source

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