A 3D In Vitro Model of the Human Hepatobiliary Junction
Advanced Science, EarlyView.A 3D human organoid platform reconstructs the hepatobiliary junction between primary adult hepatocytes and intrahepatic cholangiocytes. These adult hepatobiliary organoids (aHBOs) support directional bile transport from canaliculi to ductule‐like structures, enable quantitative imaging of junction dynamics, and reveal cell‐type‐specific vulnerabilities
Ashley D. Westerfield +13 more
wiley +1 more source
(Poly)cationic λ3-Iodane Mediated Oxidative Ring Expansion of Secondary Alcohols. [PDF]
European J Org Chem, 2018 Walters JC +3 more
europepmc +1 more source
Helix Alignment, Chevrons, and Edge Dislocations in Twist‐Bend Ferroelectric Nematics
Advanced Science, EarlyView.The recently discovered twist‐bend ferroelectric nematic (NTBF) is the new member of the multiferroic family, representing a fluid with an oblique helicoidal (heliconical) periodic structure of spontaneous electric polarization. The work presents a thorough exploration of the material properties of this phase, how the periodic modulation of ...
Bijaya Basnet +8 more
wiley +1 more source
Lithium-Catalyzed Thiol Alkylation with Tertiary and Secondary Alcohols: Synthesis of 3-Sulfanyl-Oxetanes as Bioisosteres. [PDF]
Chemistry, 2018 Croft RA, Mousseau JJ, Choi C, Bull JA.
europepmc +1 more source
Adipocyte‐Derived Leptolin Enhances Energy Expenditure and Prevents Obesity
Advanced Science, EarlyView.We identified a novel adipokine, which we named leptolin. In humans, leptolin levels in white adipose tissue were positively correlated with exercise and negatively associated with body mass index. We observed elevated leptolin in serum from athletes and lower leptolin in serum from obese individuals.
Jiarui Liu +17 more
wiley +1 more source
Optical Activity and Helicity Enhancement of Highly Sensitive Dinaphthylmethane-Based Stereodynamic Probes for Secondary Alcohols. [PDF]
ACS Omega, 2019 Mądry T, Czapik A, Kwit M.
europepmc +1 more source
Advanced Science, EarlyView.This study presents a human Bone (and Bone Marrow)‐on‐a‐Chip model based on native human bone scaffolds and autologous cells. Dynamic perfusion and sequential cell seeding replicate the physiological bone remodeling process in vitro, enabling the long‐term culture of functional, mature bone marrow immune subpopulations.
Nina Stelzer +17 more
wiley +1 more source
Advanced Science, EarlyView.Nanocellulose, derived from microcrystalline cellulose (MCC) through sulfuric acid hydrolysis or mechanical grinding to produce CNC or CNF, was tested in a rat ICP model. Particularly, CNF improved gut microbiota composition, reduced secondary bile acid metabolism, and restored bile acid homeostasis through modulation of the gut–liver axis.
Muhua Yu +18 more
wiley +1 more source
Photocatalytic carbanion generation - benzylation of aliphatic aldehydes to secondary alcohols. [PDF]
Chem Sci, 2019 Donabauer K +5 more
europepmc +1 more source
Sex‐Specific Regulation of Glycemic Homeostasis by Theabrownin from Pu‐erh Tea
Advanced Science, EarlyView.Pu‐erh tea's key component, theabrownin (TB), lowers blood glucose in a sex‐specific manner. In females, estrogen boosts intestinal MUC2 production, which dramatically enhances TB's ability to inhibit the carbohydrate‐digesting enzyme α‐glucosidase.
Yang Li +22 more
wiley +1 more source