Results 91 to 100 of about 4,045,011 (313)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Impact of a follow-up visit on two-year mortality after severe exacerbation of COPD in Finland

European Clinical Respiratory Journal
Background While guidelines recommend follow-up visits after an acute exacerbation of COPD (AECOPD), the optimal healthcare facility, timing and its effect on long-term mortality are not well known.Methods In this retrospective case–control study ...
Tanja Törölä, Paula Kauppi, Witold Mazur, Miika Linna, Jaana Keto   +4 more
doaj   +1 more source

Patients’ and healthcare professionals’ views on a specialist smoking cessation service delivered in a United Kingdom hospital: a qualitative study

Tobacco Induced Diseases, 2014
Background Hospital admission provides a powerful opportunity to promote smoking cessation. We explored patients’ and healthcare professionals’ (HCP) views of a specialist smoking cessation service comprising systematic smoking ascertainment, default ...
Manpreet Bains, John Britton, John Marsh, Leah Jayes, Rachael L Murray   +4 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Changes in smoking prevalence and cessation support, and factors associated with successful smoking cessation in Swedish patients with asthma and COPD

European Clinical Respiratory Journal, 2018
Introduction: Our aim was to investigate changes in smoking prevalence, smoking cessation support and factors associated with successful smoking cessation in patients with asthma and COPD.
Marcus Stegberg, Mikael Hasselgren, Scott Montgomery, Karin Lisspers, Björn Ställberg, Christer Janson, Josefin Sundh   +6 more
doaj   +1 more source

Initial Experiences of Building Secure Access to Patient Confidential Data via the Internet [PDF]

, 2000
A project to enable health care professionals (GPs, practice nurses and diabetes nurse specialists) to access, via the Internet, confidential patient data held on a secondary care (hospital) diabetes information system, has been implemented.
Chadwick, David W., Harvey, S., New, John, Young, Andrew J.   +3 more
core  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Rheumatic conditions associated with interstitial lung diseases: real-world outcomes in a secondary care setting

Monaldi Archives for Chest Disease
Management of rheumatic conditions associated with interstitial lung disease (r-ILD) requires expertise, often occurring in tertiary referral centers.
Alex Francioni, Muhammad K Nisar, Natasha Ramsundar, Vijay Joshi, Judeson Gnanapragasam   +4 more
doaj   +1 more source

Discharge from critical care into the community for end-of-life care [PDF]

, 2017
This article discusses the considerations and actions taken to facilitate the discharge of a ventilated end-of-life patient called Michael, whose name has been changed for confidentiality, from a critical care unit (CCU) to his expressed preferred place ...
Chambers, Anthony
core  

A feasibility, randomised controlled trial of a complex breathlessness intervention in idiopathic pulmonary fibrosis (BREEZE-IPF): study protocol [PDF]

, 2019
Introduction Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive lung disease that causes breathlessness and cough that worsen over time, limiting daily activities and negatively impacting quality of life.
Allgar, V., Cohen, J. F., Crooks, M. G., Dyson, J., English, A., Hargreaves, I., Hart, S., Hussain, J., Johnson, M., Richardson, G., Swan, F., Twiddy, M., Wright, C.   +12 more
core   +3 more sources