Results 191 to 200 of about 2,164,087 (267)

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Cytotoxic activity and safety characterization of IMV-M™, a MUC16 × DR5 bispecific antibody. [PDF]

Antib Ther
Goldmacher VS, Gershteyn IM.
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Combination of Selpercatinib and Trametinib Overcomes Resistance to RET Inhibitors in RET-Mutant Medullary Thyroid Carcinoma. [PDF]

JCO Precis Oncol
Milewski D, Fallatah A, Groff M, Rahmy A, Khan SR, Okafor C, Glassberg B, Chou HC, Heselmeyer-Haddad K, Wangsa D, Wangsa D, Kim Y, Isanogle K, Song Y, Zhang X, Thomas C, Difilippantonio S, Park JI, Wei JS, Hawley RG, Glod J, Khan J.   +21 more
europepmc   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

A rare calvarial aneurysmal bone cyst in an adult: Case report and literature review. [PDF]

Surg Neurol Int
Rushetsky ZM, Zussman B.
europepmc   +1 more source

Neuroprotection After Intracerebral Hemorrhage: Apoptosis, Neurogenesis, and Prospects of Stem Cell Therapy. [PDF]

Stem Cells Int
Wang Z, Tian J, Kong Y.
europepmc   +1 more source

Circadian Regulation of Gut Microbial Metabolites in Intestinal Epithelial Homeostasis. [PDF]

Metabolites
Park M, Kim S, Choe J.
europepmc   +1 more source

Stress-induced MAPK (SIMK)-dependent organization of microtubules in alfalfa. [PDF]

Mol Hortic
Hlaváčková K, Ovečka M, Šamajová O, Šamaj J.   +3 more
europepmc   +1 more source

Vascularized Iris Mass as Sentinel Manifestation of Syphilis in Patient with HIV Infection, Spain, 2025. [PDF]

Emerg Infect Dis
Caminal-Caramés M, Sánchez-Serra J, Díaz-Cascajosa J, Saladrigas A, Conversa S, Vela-Segarra JI.   +5 more
europepmc   +1 more source