Results 231 to 240 of about 2,231,961 (316)

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Resolving sensitivity, specificity and signal contamination in Xenium spatial transcriptomics. [PDF]

Nat Methods
Bilous M, Buszta D, Bac J, Kang S, Dong Y, Tissot S, Andre S, Alexandre Gaveta M, Voize C, Peters S, Homicsko K, Gottardo R.   +11 more
europepmc   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Neuroprotection After Intracerebral Hemorrhage: Apoptosis, Neurogenesis, and Prospects of Stem Cell Therapy. [PDF]

Stem Cells Int
Wang Z, Tian J, Kong Y.
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Stress-induced MAPK (SIMK)-dependent organization of microtubules in alfalfa. [PDF]

Mol Hortic
Hlaváčková K, Ovečka M, Šamajová O, Šamaj J.   +3 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

A kinetics-based model of haematopoiesis reveals extrinsic regulation of skewed lineage output from stem cells. [PDF]

Nat Cell Biol
Rodríguez-Correa E, Grünschläger F, Nizharadze T, Anstee N, Al-Sabah J, Kumpost V, Sedlmeier A, Li C, Ball M, Fotopoulou F, Jayarajan J, Ghezzi I, Knoch J, Druce M, Aurich K, Büchler-Schäff M, Lux S, Hernández-Malmierca P, Gräsel J, Vonficht D, López-Osias M, González-Saiz E, Fernández-Pérez D, Mathioudaki A, Zaugg J, Rodríguez-Fraticelli A, Mikut R, Trumpp A, Höfer T, Hübschmann D, Haas S, Milsom MD.   +31 more
europepmc   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Clonal hematopoiesis of indeterminate potential in high grade B-cell lymphomas: clinicobiological associations and further insight with single-cell multiomics analysis. [PDF]

Blood Cancer J
Hesselager C, Hollander P, Pettersson E, Enblad G, Weström S, Nord H, Munters AR, Almlöf J, Eriksson D, Baliakas P, Amini RM.   +10 more
europepmc   +1 more source