Results 51 to 60 of about 2,164,087 (267)

Bruton’s tyrosine kinase inhibition reduces disease severity in a model of secondary progressive autoimmune demyelination

Acta Neuropathologica Communications, 2023
Bruton’s tyrosine kinase (BTK) is an emerging target in multiple sclerosis (MS). Alongside its role in B cell receptor signaling and B cell development, BTK regulates myeloid cell activation and inflammatory responses. Here we demonstrate efficacy of BTK
Kirsten Scarlett Evonuk, Sen Wang, Josh Mattie, C. J. Cracchiolo, Reine Mager, Željko Ferenčić, Ethan Sprague, Brandon Carrier, Kai Schofield, Evelyn Martinez, Zachary Stewart, Tara Petrosino, Gregory Andrew Johnson, Isharat Yusuf, Warren Plaisted, Zachary Naiman, Timothy Delp, Laura Carter, Suzana Marušić   +18 more
doaj   +1 more source

The Relationship Between Physical Activity and Left Ventricular Remodeling in Childhood Cancer Survivors Treated With Anthracyclines: A Cross‐Sectional Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Anthracycline‐related cardiac remodeling precedes heart failure in childhood cancer survivors. The objectives of this study were to determine the relationships between patient‐specific factors, moderate‐to‐vigorous physical activity (MVPA), and cardiac remodeling.
Hari K. Narayan, Sitong Chen, F. Lennie Wong, Nathan Young, Anna Qi, Christopher Davis, Sanjeet Hegde, Nicholas Gloude, Kasey J. Leger, Kelly D. Getz, Francisco Contijoch, Kirsten Ness, Bonnie Ky, Dennis Kuo, Sheri J. Hartman, Saro H. Armenian   +15 more
wiley   +1 more source

The homeodomain protein defective proventriculus is essential for male accessory gland development to enhance fecundity in Drosophila. [PDF]

PLoS ONE, 2012
The Drosophila male accessory gland has functions similar to those of the mammalian prostate gland and the seminal vesicle, and secretes accessory gland proteins into the seminal fluid.
Ryunosuke Minami, Miyuki Wakabayashi, Seiko Sugimori, Kiichiro Taniguchi, Akihiko Kokuryo, Takao Imano, Takashi Adachi-Yamada, Naoko Watanabe, Hideki Nakagoshi   +8 more
doaj   +1 more source

Childhood Acute Lymphoblastic Leukemia Survival in Western Kenya: Reduction in Early Deaths and Treatment Abandonment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background An earlier study on children diagnosed with acute lymphoblastic leukemia (ALL) at Moi Teaching and Referral Hospital (MTRH) in Kenya reported a low event‐free survival (EFS), excess treatment abandonment, and high induction mortality.
Gilbert Olbara, George Bogonko, Festus Njuguna, Sandra Langat, Martha Kipngetich, Dennis Njenga, Gertjan Johannes Kaspers, Terry Allen Vik   +7 more
wiley   +1 more source

Distributed equalisation strategy for multi-battery energy storage systems

The Journal of Engineering, 2019
Multi-battery energy storage systems (MBESSs) are widely adopted to overcome the uncertainty problem of renewable energy sources. However, state-of-charge (SOC) imbalance issue of MBESSs brings great challenges to the optimal dispatching strategy and the
Feilong Fan, Nengling Tai, Wentao Huang, Xiaodong Zheng, Chunju Fan   +4 more
doaj   +1 more source

The immunosenescence-related factor DOCK11 is involved in secondary immune responses of B cells

Immunity & Ageing, 2022
Background Memory B cells are an antigen-experienced B-cell population with the ability to rapidly differentiate into antibody-producing cells by recall responses.
Yuma Sugiyama, Mitsuhiro Fujiwara, Akihiko Sakamoto, Hiromichi Tsushima, Akihiko Nishikimi, Mitsuo Maruyama   +5 more
doaj   +1 more source

Misperception of Body Weight After Childhood Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Misperception of body weight can negatively impact the weight management efforts of childhood cancer survivors (CCSs). Both being overweight or underweight are associated with chronic health conditions commonly observed in CCS; therefore, accurate weight perception is critical for reducing long‐term health risks.
Fabiën N. Belle, Tomáš Sláma, Eva Haegler‐Laube, Reto D. Kurmann, Gabriela M. Kuster, Christoph Saner, Eva Scheler, Yara Shoman, Christina Schindera   +8 more
wiley   +1 more source

Optimal control strategy of load aggregators with demand response

The Journal of Engineering, 2018
This study presents an optimal control strategy for a load aggregator (LA) with demand response. The LA can provide consumers with time-of-use electricity price which could be different with the selling price of electricity by power grid.
Xiao Zhou, Jing Shi, Jing Shi, Shujian Li   +3 more
doaj   +1 more source

Antigen-Specific CD4+ T Cells Exhibit Distinct Kinetic and Phenotypic Patterns During Primary and Secondary Responses to Infection

Frontiers in Immunology, 2020
Although CD4+ T cell memory is a critical component of adaptive immunity, antigen-specific CD4+ T cell recall responses to secondary infection have been inadequately studied.
Deepali Malhotra, Kristina S. Burrack, Kristina S. Burrack, Marc K. Jenkins, Anne E. Frosch, Anne E. Frosch   +5 more
doaj   +1 more source

Solid Pseudopapillary Neoplasm of the Pancreas in Children and Adolescents: Expert Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Solid pseudopapillary neoplasm of the pancreas (SPN) is a rare low‐grade malignant exocrine pancreatic tumor, mostly discovered during the second decade of life in females, with a very good prognosis, provided microscopically complete surgical excision is achieved.
Sabine Irtan, Michael Abele, Calogero Virgone, Michaela Kuhlen, Ricardo Lopez‐Almarez, Tal Ben‐Ami, Ewa Bien, Maja Cesen, Malgorzata A. Krawczyk, Andrea Ferrari, Gianni Bisogno, Yves Reguerre, Dominik T. Schneider, Louise Galmiche, Jorg Fuchs, Sarah Braungart, Bilgehan Yalcin, Ines B. Brecht, Daniel Orbach   +18 more
wiley   +1 more source