Results 61 to 70 of about 1,860,659 (307)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Interdisciplinary Thematic Learning in Mathematics Education for Primary and Secondary Schools: Changes, Connotations, and Implementation

Jiaoshi jiaoyu xuebao
Interdisciplinary thematic learning in mathematics education for primary and secondary schools is considered an important approach to promote educational reforms.
ZHANG Tingyan, SUN Xiaotian, HU Na
doaj   +1 more source

Análisis de las especialidades de Física y Química y de Biología y Geología del máster de profesorado de educación secundaria de la Universidad de Valencia [PDF]

, 2013
Empezamos este trabajo mostrando los problemas que plantea la formación inicial del profesorado de ciencias. A continuación se realiza una descripción de la estructura del Máster de Profesorado de Educación Secundaria de la Universidad de Valencia y de ...
Gavidia Catalán, Valentín, Solbes Matarredona, Jordi   +1 more
core   +4 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Applying university strategic objectives at the school level [PDF]

, 2014
University Teachers at the School of Interdisciplinary Studies are working together on the Teaching, Learning and Participation Project. This project encompasses three strands: widening participation, student experience, and innovative learning and ...
Cavani, Jane, Ferguson, Esther, Pate, A. Graeme, Rinaldi, Carlo, Wood, Bethan   +4 more
core  

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Opinions of Socially Excluded Individuals on Conducting Business Activity and Being Employed on a full-time Basis in View of Iwn Research

Prace Naukowe Uniwersytetu Ekonomicznego we Wrocławiu, 2019
The main objective of the considerations presented in the article is the attempt to verify the opinion of excluded individuals on conducting a business activity and being employed on a full-time basis.
Mariola Szewczyk-Jarocka
doaj  

Zeitgeist: information literacy and educational change [PDF]

, 2005
Information literacy is a mosaic of attitudes, understandings, capabilities and knowledge about which there are three myths. The first myth is that it is about the ability to use ICTs to access a wealth of information.
Bundy, Alan
core  

HYGIENIC ASSESSMENT OF CATERING IN SECONDARY PROFESSIONAL EDUCATION ORGANIZATIONS

Здоровье населения и среда обитания - ЗНиСО, 2019
We evaluated diets for students of secondary vocational education organizations in Chelyabinsk. Students of secondary vocational education organizations are provided with one- or two-time organized meals at the expense of the regional budget, as well as additional food in the form of pantry products.
G.M. Nasybullina, S.S. Delets
openaire   +1 more source