Results 71 to 80 of about 5,897,692 (241)

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Effect of the surface processing on the secondary electron yield of Al alloy samples

Physical Review Special Topics. Accelerators and Beams, 2013
In this study we have investigated the relation between the secondary electron yield (SEY) and the surface chemical state for technical Al alloy samples cut from the inner walls of the Petra III storage ring.
D. R. Grosso, M. Commisso, R. Cimino, R. Larciprete, R. Flammini, R. Wanzenberg   +5 more
doaj   +1 more source

Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley   +1 more source

Coupled bunch instability caused by an electron cloud

Physical Review Special Topics. Accelerators and Beams, 2006
A coupled-bunch instability caused by an electron cloud has been observed in the KEKB LER. The time evolution of the instabilities just after the turning-off the transverse bunch feedback was recorded with several weak solenoid-field conditions, which ...
M. Tobiyama, J. W. Flanagan, H. Fukuma, S. Kurokawa, K. Ohmi, S. S. Win   +5 more
doaj   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Experimental efforts at LNF to reduce secondary electron yield in particle accelerators

, 2013
A common effort in most accelerator centres is to develop new technologies to produce and test beam pipe inner walls of particle accelerators with an as low as possible Secondary Electron Yield (SEY).
Cimino R., Commisso M., Grosso D. R., Demma T., Giglia A., Mahne N.   +5 more
core  

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

Secondary Electron Yield and Groove Chamber Tests in PEP-II [PDF]

, 2007
Possible remedies for the electron cloud in positron damping ring (DR) of the International Linear Collider (ILC) includes thin-film coatings, surface conditioning, photon antechamber, clearing electrodes and chamber with grooves or slots [1].
T. Markiewicz, Raubenheimer, Tor O., J. Seeman, L. Wang, Seeman, J., R. Kirby, M. Pivi, Wang, L., F. Le Pimpec, Le Pimpec, F., G. Collet, T. Raubenheimer, Markiewicz, Thomas W., F. King, Kirby, R.E., Pivi, MTF   +15 more
core   +2 more sources